Results 91 to 100 of about 803,603 (305)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Finding the Integrated Care Evidence Base in PubMed and Beyond: A Bibliometric Study of the Challenges

International Journal of Integrated Care, 2018
Introduction: Integrated care research evidence should be optimally visible and accessible to stakeholders. This study examines the contribution of specific databases to the discovery of integrated care evidence, and tests the usefulness of Medical ...
Suzanne Lewis, Raechel A. Damarell, Jennifer J. Tieman, Camilla Trenerry   +3 more
doaj   +1 more source

The Bionic Radiologist: avoiding blurry pictures and providing greater insights [PDF]

, 2019
Radiology images and reports have long been digitalized. However, the potential of the more than 3.6 billion radiology examinations performed annually worldwide has largely gone unused in the effort to digitally transform health care.
Dewey, Marc, Wilkens, Uta
core   +1 more source

Integration of health care delivery in the Eastern Mediterranean Region of the World Health Organization

Eastern Mediterranean Health Journal, 2000
This paper reviews developments in the integration of health care delivery in the Eastern Mediterranean Region. It describes the integrated intersectoral support of socioeconomic community development [district health systems and basic development needs], the functional intrasectoral integration of health services and interventions, and health ...
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Help me understand what is important to you, co-designing outcome measures that matter to people: A systematic review of the literature

International Journal of Integrated Care, 2019
Taking many forms across contextually diverse and complex settings, models of health care delivery described as integrated, commonly share an assumption that the model will improve the individuals experience and enable the individual to be in a better ...
Karen Patterson, Debra Jackson, Joanne Travaglia   +2 more
doaj   +1 more source

Integrated care: What policies support and influence integration in health care across New Zealand, England, Canada and the United States? [PDF]

, 2013
One of the key challenges for health systems worldwide is the substantial cost of fragmented care, not only financially, but also in terms of patient and population health. In light of this, integrated health care has been a key element of health reforms
Brown, Lynsey, Bywood, Petra Teresia, Oliver-Baxter, Jodie   +2 more
core  

Exploring the Feasibility of Service Integration in a Low-Income Setting: A Mixed Methods Investigation into Different Models of Reproductive Health and HIV Care in Swaziland. [PDF]

, 2015
Integrating reproductive health (RH) with HIV care is a policy priority in high HIV prevalence settings, despite doubts surrounding its feasibility and varying evidence of effects on health outcomes.
Alison Wringe, B Ekman, BG Glaser, CE Warren, CF Gilks, D Georgeu, D Grossman, D McCoy, F Dwamena, FE Harrell Jr., George B. Ploubidis, H Coovadia, H Schneider, HW Reynolds, J Shelton, JA Smit, JN Baumgartner, K Church, K Church, K Church, K Church, K Uebel, Kathryn Church, Kebede Deribe, L Lush, L Lush, L Myer, M Dixon-Woods, M Rabkin, M Sibide, ML Lindegren, N Leon, Phelele Fakudze, R Mutemwa, R Pawson, R Yin, S Reeves, S Reeves, Simon Lewin, SM Topp, Susannah H. Mayhew, WM El-Sadr   +41 more
core   +4 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Strengthening the delivery of integrated care for individuals experiencing serious mental illness within mental health settings: a qualitative description of health provider perspectives

BMC Psychiatry
Background Individuals experiencing serious mental illness (SMI) have higher rates of comorbid physical health conditions, poorer associated health outcomes, and die on average 10–20 years earlier than the general population.
Munazzah Ambreen, Christopher Canning, Brian Lo, Sri Mahavir Agarwal, Amer M. Burhan, David Castle, M. Elisabeth Del Giudice, Barna Konkolÿ-Thege, Louis Liu, Osnat C. Melamed, Frank Sirotich, Sanjeev Sockalingam, Gillian Strudwick, Tania Tajirian, Philip G. Tibbo, Mary Rose van Kesteren, Caroline Walker, Vicky Stergiopoulos   +17 more
doaj   +1 more source