Results 91 to 100 of about 7,677,076 (348)

Promotion of Service Delivery in Terms of the Social Contract Theory in South Africa's Legal Framework

open access: yesPotchefstroom Electronic Law Journal
As is evident in the prevailing water and electricity rationing, South Africa is reeling from a crisis of poor service delivery. Against the background of its apartheid history and liberal constitution, this article examines how South Africa's legal ...
Ebi Okeng, Anthony Chima Diala
doaj   +1 more source

Does Ownership Matter for Medical System Performance? Evidence From a Natural Experiment in Suqian, China

open access: yesInquiry: The Journal of Health Care Organization, Provision, and Financing, 2020
There has long been a major policy debate on the role of hospital ownership (private vs public) in medical system performance. China’s health care delivery system is mainly a public system. In 2000, a full privatization reform was implemented in the city
Gordon G. Liu PhD   +4 more
doaj   +1 more source

Nanoengineering facilitating the target mission: targeted extracellular vesicles delivery systems design

open access: yesJournal of Nanobiotechnology, 2022
Highlights 1. Tracing the full range of factors affecting EVs targeting mission in terms of EV components, cell sources, and delivery methods. 2. Strategies for EVs surface display and post-isolation methods facilitate the targeted delivery efficiency of
Haoyue Song   +5 more
doaj   +1 more source

Development of an optimised application protocol for sonophoretic transdermal delivery of a model hydrophilic drug

open access: yes, 2011
It has now been known for over a decade that low frequency ultrasound can be used to effectively enhance transdermal drug penetration - an approach termed sonophoresis.
Abdul, Rasool   +3 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

open access: yesJournal of Nanobiotechnology, 2019
Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological information between cells. However, Exo are limited in terms of their abilities to target specific recipient cell types.
Chunai Gong   +10 more
semanticscholar   +1 more source

Nanostructured hyaluronic acid-based materials for active delivery to cancer

open access: yes, 2010
Importance of the field: Active targeting of bioactive molecules by physicochemical association with hyaluronic acid ( HA) is an attractive approach in current nanomedicine because HA is biocompatible, non-toxic and non-inflammatory.
Ossipov, Dmitri A.,
core   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Long-term Intraperitoneal Insulin Delivery

open access: yesAnnals of Surgery, 1992
Over the past 5 years, 21 patients with insulin-dependent diabetes mellitus have been managed at the Johns Hopkins Medical Institutions with variable rate, remotely controlled implanted insulin pumps. To date, nearly 70 patient-years of experience has been gained with intraperitoneal delivery of a new U-400 insulin with a surfactant.
H A, Pitt, C D, Saudek, H A, Zacur
openaire   +3 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Home - About - Disclaimer - Privacy