Results 51 to 60 of about 326,141 (263)

Detecting Overexpression Level of HER2 Gene in NSCLC by Real-time Quantitative PCR and the 2[-Delta Delta C(T)] Method

Chinese Journal of Lung Cancer, 2011
Background and objective The evaluation of the expression level of the HER2 gene for the diagnosis and treatment of tumors is usually conducted using immunohistochemical techniques.
Shuidong FENG, Hongzhuan TAN, Hongyan LING, Xiuqin YUAN   +3 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

An Improved Delta-Centralization Method for Population Stratification [PDF]

Human Heredity, 2011
Dadd et al. [Hum Hered 2010;69:285–294] recently criticized our delta-centralization (DC) method of controlling for population stratification (PS) and concluded that DC does not work. To explore our method, the authors simulated data under the Balding-Nichols (BN) model, which is more general than the model we had used in our simulations.
Prakash, Gorroochurn, Susan E, Hodge, Gary A, Heiman, David A, Greenberg   +3 more
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Multiple periodic solutions for the second-order nonlinear difference equations

Advances in Difference Equations, 2018
Multiple periodic solutions for the equation Δ(pn(Δxn−1)δ)+qnxnδ=∇F(n,xn),n∈Z, $$ \Delta \bigl(p_{n}(\Delta x_{n - 1})^{\delta } \bigr) + q_{n}x_{n}^{\delta } = \nabla F ( n,x_{n} ) , \quad n \in \mathbb{Z}, $$ are obtained via variational method and ...
Sheng Ma, Zhihua Hu, Qin Jiang
doaj   +1 more source

Delta methods in enveloping rings

Journal of Algebra, 1990
Let L be a Lie algebra over a field K of characteristic 0 with a universal enveloping algebra U(L) (or a restricted Lie algebra with restricted enveloping algebra u(L) when char K\(=p>0)\) and let L act on a K-algebra R as K-derivations. The authors consider the twisted smash products R{\#}U(L) and R{\#}u(L).
Bergen, Jeffrey, Passman, D.S
openaire   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Hardware-Efficient Delta Sigma-Based Digital Signal Processing Circuits for the Internet-of-Things

Journal of Low Power Electronics and Applications, 2015
This paper presents hardware-efficient Delta Sigma linear processing circuits for the next generation low-power VLSI devices in the Internet-of-things (IoT).We first propose the P-N (positive-negative) pair method to manipulate both the analog value and ...
Yifei Liu, Paul M. Furth, Wei Tang
doaj   +1 more source