Results 61 to 70 of about 326,141 (263)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Inference for the Chris–Jerry Lifetime Distribution Under Improved Adaptive Progressive Type-II Censoring for Physics and Engineering Data Modelling

Axioms
This paper presents a comprehensive reliability analysis framework for the Chris–Jerry (CJ) lifetime distribution under an improved adaptive progressive Type-II censoring plan.
Heba S. Mohammed, Osama E. Abo-Kasem, Ahmed Elshahhat   +2 more
doaj   +1 more source

Convergence of the EM method for NSDEs with time-dependent delay in the G-framework

Systems Science & Control Engineering, 2019
Consider a neutral stochastic differential equation (NSDE) with time-dependent delay $\delta (t) $ ( $0 \le \delta (t) \le \tau $) in the G-framework $$\begin{align*} {\rm d}(x(t) - D ( x(t - \delta (t)))) & = f(x(t), x(t-\delta(t)))\,{\rm d}t \\ & \quad
Shounian Deng, Yong Liang, Chunhui Mei
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Interval Estimation for the Difference and Ratio of Variances Under the Zero-Inflated Two-Parameter Rayleigh Distribution

Mathematics
The zero-inflated two-parameter Rayleigh (ZITR) distribution provides a flexible framework for modeling data with excess zeros and positive observations following a two-parameter Rayleigh distribution.
Sasipong Kijsason, Sa-Aat Niwitpong, Suparat Niwitpong   +2 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Razões de proporções e uso do método delta para intervalos de confiança em regressão logística

Revista de Saúde Pública
OBJETIVO: Apresentar uma aplicação da regressão logística para estimar razões de prevalência ou risco relativo, e o uso do método delta para a estimativa de intervalos de confiança.
Nelson F. de Oliveira, Vilma S. Santana, Antonio Alberto Lopes   +2 more
doaj  

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source