Results 61 to 70 of about 1,388 (138)

HTLV-1 NA LEUCEMIA/LINFOMA DE CÉLULAS-T E ABORDAGEM SOCIAL SOBRE A INFECÇÃO

Arquivos de Ciências da Saúde da UNIPAR, 2023
A Leucemia/Linfoma de Células-T do Adulto (LLCT) é um tipo agressivo de doença linfoproliferativa causada pelo Vírus Linfotrópico de Células-T Humano (HTLV-1), classificada em cinco tipos: indolente, tumoral primária de pele, crônico, linfomatoso e agudo.
Rafael Braz De Almeida
semanticscholar   +1 more source

Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

Retrovirology, 2007
In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the ...
Burny Arsène, Defoiche Julien, Bouzar Amel-Baya, Balon Hervé, Vandermeers Fabian, Nigro Annamaria, Burteau Catherine, Boxus Mathieu, Florins Arnaud, Gillet Nicolas, Reichert Michal, Kettmann Richard, Willems Luc   +12 more
doaj   +1 more source

Post-transcriptional Regulation of HTLV Gene Expression: Rex to the Rescue

Frontiers in Microbiology, 2019
Human T-lymphotropic virus type 1 (HTLV-1) and other members of the Deltaretrovirus genus code for a regulatory protein named Rex that binds to the Rex-responsive element present on viral mRNAs.
Donna M. D’Agostino, Ilaria Cavallari, Maria Grazia Romanelli, Vincenzo Ciminale, Vincenzo Ciminale   +4 more
doaj   +1 more source

Vulnerability to APOBEC3G linked to the pathogenicity of deltaretroviruses

Proceedings of the National Academy of Sciences of the United States of America
Significance Cross-species transmission of viruses is frequently linked to increased pathogenicity. HIV-1 causes AIDS in humans, while SIV-1 is not as pathogenic in its natural hosts.
T. Shichijo, Jun-ichirou Yasunaga, Kei Sato, K. Nosaka, K. Toyoda, Miho Watanabe, Wenyi Zhang, Yoshio Koyanagi, Edward L Murphy, Roberta Bruhn, K. Koh, Hirofumi Akari, Terumasa Ikeda, R. Harris, Patrick L Green, Masao Matsuoka   +15 more
semanticscholar   +1 more source

Effects of Naturally Occurring Mutations in Bovine Leukemia Virus 5′-LTR and Tax Gene on Viral Transcriptional Activity

Pathogens, 2020
Bovine leukemia virus (BLV) is a deltaretrovirus infecting bovine B cells and causing enzootic bovine leucosis (EBL). The long terminal repeat (LTR) plays an indispensable role in viral gene expression. The BLV Tax protein acts as the main transactivator
Aneta Pluta, Luc Willems, Renée N. Douville, Jacek Kuźmak   +3 more
doaj   +1 more source

Cabotegravir, the Long-Acting Integrase Strand Transfer Inhibitor, Potently Inhibits Human T-Cell Lymphotropic Virus Type 1 Transmission in vitro

Frontiers in Medicine, 2022
Human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus most prevalent in southwestern Japan, sub-Saharan Africa, Australia, South America, and the Caribbean. Latest figures approximate 10 million people worldwide to be infected with HTLV-1.
Bethany S. Schneiderman, Michal S. Barski, Goedele N. Maertens   +2 more
doaj   +1 more source

Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads

Retrovirology, 2009
Background Bovine Leukemia virus (BLV) is a deltaretrovirus that induces lymphoproliferation and leukemia in ruminants. In ex vivo cultures of B lymphocytes isolated from BLV-infected sheep show that spontaneous apoptosis is reduced.
François Carole, Florins Arnaud, Boxus Mathieu, Bouzar Amel, Reichert Michal, Willems Luc   +5 more
doaj   +1 more source

Potential Risk Factors Associated with Infection with Bovine Leukaemia Virus in Dairy and Beef Cattle in Taiwan

Pathogens, 2021
Bovine leukaemia virus (BLV), which is classified as a Deltaretrovirus, is the aetiologic agent of enzootic bovine leukosis (EBL), a chronic lymphoproliferative disorder with a worldwide distribution.
Yi-Chen Chen, Wen-Yu Chin, Chao-Chin Chang, Shih-Te Chuang, Wei-Li Hsu   +4 more
doaj   +1 more source

Cell Culture Evaluation Hints Widely Available HIV Drugs Are Primed for Success if Repurposed for HTLV-1 Prevention

Pharmaceuticals
With an estimated 10 million people infected, the deltaretrovirus human T-cell lymphotropic virus type 1 (HTLV-1) is the second most prevalent pathogenic retrovirus in humans after HIV-1.
Mphatso D. Kalemera, Allison K. Maher, Margarita Dominguez-Villar, G. Maertens   +3 more
semanticscholar   +1 more source

Bovine Leukemia Virus DNA in Human Breast Tissue

Emerging Infectious Diseases, 2014
Bovine leukemia virus (BLV), a deltaretrovirus, causes B-cell leukemia/lymphoma in cattle and is prevalent in herds globally. A previous finding of antibodies against BLV in humans led us to examine the possibility of human infection with BLV. We focused
Gertrude Case Buehring, Hua Min Shen, Hanne M. Jensen, K. Yeon Choi, Dejun Sun, Gerard Nuovo   +5 more
doaj   +1 more source