Results 61 to 70 of about 2,325 (179)

Phosphorylation regulates human T-cell leukemia virus type 1 Rex function [PDF]

, 2009
Background: Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic complex deltaretrovirus, which is the causative agent of adult T-cell leukemia/lymphoma (ATL) and HTLV- 1-associated myelopathy/tropical spastic paraparesis.
Doueiri, Rami, Green, Patrick L., Kesic, Matthew, Semmes, O. John, Ward, Michael   +4 more
core   +2 more sources

HTLV‐1‐Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL‐28B Gene

Mediators of Inflammation, Volume 2015, Issue 1, 2015., 2015
The present study investigated the association between the rs12979860 polymorphism in the IL‐28B gene and HTLV‐1 infection as well as the development of HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV‐1‐infected patients (26 HAM/TSP symptomatic and 53 asymptomatic) and 300 seronegative healthy controls were investigated ...
Antonio C. R. Vallinoto, Bárbara Brasil Santana, Keyla S. G. Sá, Tuane C. S. Ferreira, Rita Catarina M. Sousa, Vânia N. Azevedo, Rosimar N. M. Feitosa, Luiz Fernando A. Machado, Marluísa O. G. Ishak, Ricardo Ishak, Mukesh Kumar   +10 more
wiley   +1 more source

Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivo [PDF]

, 2008
Background: Human T-cell leukemia virus (HTLV) type 1 and type 2 are related but distinct pathogenic complex retroviruses. HTLV-1 is associated with adult T-cell leukemia and a variety of immune-mediated disorders including the chronic neurological ...
Brenda Yamamoto, Ihab Younis, Matthew Kesic, Michael D Lairmore, Min Li, Patrick L Green   +5 more
core   +3 more sources

The Role of Cytidine Deaminases on Innate Immune Responses against Human Viral Infections

BioMed Research International, Volume 2013, Issue 1, 2013., 2013
The APOBEC family of proteins comprises deaminase enzymes that edit DNA and/or RNA sequences. The APOBEC3 subgroup plays an important role on the innate immune system, acting on host defense against exogenous viruses and endogenous retroelements. The role of APOBEC3 proteins in the inhibition of viral infection was firstly described for HIV‐1. However,
Valdimara C. Vieira, Marcelo A. Soares, Enrique Medina-Acosta   +2 more
wiley   +1 more source

Complex Codon Usage Pattern and Compositional Features of Retroviruses

Computational and Mathematical Methods in Medicine, Volume 2013, Issue 1, 2013., 2013
Retroviruses infect a wide range of organisms including humans. Among them, HIV‐1, which causes AIDS, has now become a major threat for world health. Some of these viruses are also potential gene transfer vectors. In this study, the patterns of synonymous codon usage in retroviruses have been studied through multivariate statistical methods on ORFs ...
Sourav RoyChoudhury, Debaprasad Mukherjee, Kazuhisa Nishizawa   +2 more
wiley   +1 more source

Human T-Lymphotropic Virus (HTLV): Epidemiology, Genetic, Pathogenesis, and Future Challenges

Viruses
Human T-lymphotropic viruses (HTLVs) are deltaretroviruses infecting millions of individuals worldwide, with HTLV-1 and HTLV-2 being the most widespread and clinically relevant types.
Francesco Branda, Chiara Romano, Grazia Pavia, Viola Bilotta, Chiara Locci, Ilenia Azzena, Ilaria Deplano, Noemi Pascale, Maria Perra, Marta Giovanetti, Alessandra Ciccozzi, Andrea De Vito, Angela Quirino, Nadia Marascio, Giovanni Matera, Giordano Madeddu, Marco Casu, Daria Sanna, Giancarlo Ceccarelli, Massimo Ciccozzi, Fabio Scarpa   +20 more
doaj   +1 more source

Silent pressure: Unveiling spinal lymphoma in horses and its parallels to other species

Equine Veterinary Education, EarlyView.
Summary Though the nervous system is an uncommon location for lymphoma, the disease should remain a differential diagnosis in some cases of ataxia in equids. Diagnosis of lymphoma can be challenging, although a combination of cytology, histopathology and immunophenotyping can aid in definitive diagnosis and therefore more accurately guide treatment and
H. E. Taylor, D. Luethy
wiley   +1 more source

Immunopathogenesis of Human T‐Cell Leukemia Virus Type‐1‐Associated Myelopathy/Tropical Spastic Paraparesis: Recent Perspectives

Leukemia Research and Treatment, Volume 2012, Issue 1, 2012., 2012
Human T‐cell leukemia virus type‐1 (HTLV‐1) is a replication‐competent human retrovirus associated with two distinct types of disease only in a minority of infected individuals: the malignancy known as adult T‐cell leukemia (ATL) and a chronic inflammatory central nervous system disease HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Mineki Saito, Charles R. M. Bangham, Pooja Jain   +2 more
wiley   +1 more source

Exploring the presence of bovine leukemia virus among breast cancer tumors in a rural state

Breast Cancer Research and Treatment, 2023
Purpose The bovine leukemia virus (BLV) is a deltaretrovirus that causes malignant lymphoma and lymphosarcomas in cattle globally and has high prevalence among large scale U.S. dairy herds. Associations between presence of BLV DNA in human mammary tissue
S. Amato, Jon Ramsey, T. Ahern, J. Rovnak, J. Barlow, D. Weaver, Lud Eyasu, Rohit Singh, J. Cintolo-Gonzalez   +8 more
semanticscholar   +1 more source

Cotranscriptional Chromatin Remodeling by Small RNA Species: An HTLV‐1 Perspective

Leukemia Research and Treatment, Volume 2012, Issue 1, 2012., 2012
Cell type specificity of human T cell leukemia virus 1 has been proposed as a possible reason for differential viral outcome in primary target cells versus secondary. Through chromatin remodeling, the HTLV‐1 transactivator protein Tax interacts with cellular factors at the chromosomally integrated viral promoter to activate downstream genes and control
Nishat Aliya, Saifur Rahman, Zafar K. Khan, Pooja Jain, Mineki Saito   +4 more
wiley   +1 more source