Viruses, 2022 The bovine leukemia virus (BLV) and the human T-lymphothropic viruses (HTLVs) are members of the deltaretrovirus genus of Retroviridae family. An essential event of the retroviral life cycle is the processing of the polyproteins by the viral protease (PR)
János András Mótyán +3 more
doaj +2 more sources
No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms [PDF]
Retrovirology, 2007 Background The Deltaretrovirus genus comprises viruses that infect humans (HTLV), various simian species (STLV) and cattle (BLV). HTLV-I is the main causative agent in adult T-cell leukemia in endemic areas and some of the simian T-cell lymphotropic ...
Hoelzer Dieter +4 more
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Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures [PDF]
Nature Communications, 2021 Human T-cell lymphotropic virus type 1 (HTLV-1) is an oncogenic deltaretrovirus. Here the authors provide structural characterization of the binding mechanism of novel integrase strand transfer inhibitor (INSTI) candidates to limit HTLV-1 infection.
Michal S. Barski +10 more
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Molecular Studies of HTLV-1 Replication: An Update
Viruses, 2016 Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered. Studies on HTLV-1 have been instrumental for our understanding of the molecular pathology of virus-induced cancers.
Joachim Mueller +2 more
exaly +3 more sources
Distinct Morphology of Human T-Cell Leukemia Virus Type 1-Like Particles
Viruses, 2016 The Gag polyprotein is the main retroviral structural protein and is essential for the assembly and release of virus particles. In this study, we have analyzed the morphology and Gag stoichiometry of human T-cell leukemia virus type 1 (HTLV-1)-like ...
Sheng Cao +2 more
exaly +3 more sources
Early and transient reverse transcription during primary deltaretroviral infection of sheep [PDF]
Retrovirology, 2008 Background Intraindividual genetic variability plays a central role in deltaretrovirus replication and associated leukemogenesis in animals as in humans. To date, the replication of these viruses has only been investigated during the chronic phase of the
Wattel Eric +7 more
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New Insights into HTLV-1 Particle Structure, Assembly, and Gag-Gag Interactions in Living Cells
Viruses, 2011 Human T-cell leukemia virus type 1 (HTLV-1) has a reputation for being extremely difficult to study in cell culture. The challenges in propagating HTLV-1 has prevented a rigorous analysis of how these viruses replicate in cells, including the detailed ...
Joachim Mueller +2 more
exaly +3 more sources
Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human [PDF]
Retrovirology, 2007 In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the ...
Burny Arsène +12 more
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Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ [PDF]
Nature Communications, 2020 Human T-cell lymphotropic virus type 1 (HTLV-1) is a pathogenic deltaretrovirus. Here the authors resolve the cryo-EM structure of the deltaretroviral intasome in complex with the human host PP2A regulatory subunit.
Michał S. Barski +6 more
doaj +3 more sources
Engineered soluble truncated envelope proteins block bovine leukemia virus infection [PDF]
Virus ResearchBovine leukemia virus (BLV), a member of the delta retrovirus family, is transmitted horizontally among cows. BLV causes enzootic bovine leukosis and has great economic impact on the cattle industry.
Nashon Wanjala +4 more
doaj +2 more sources