Results 41 to 50 of about 37,908 (263)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Why Urban Mass Demand Responsive Transport? [PDF]
2011 IEEE Forum on Integrated and Sustainable Transportation Systems, 2011 In this paper, we argue that a large-scale demand responsive system is the missing element from the spectrum of the urban transport modes. To this end, we provide a comprehensive analysis addressing this broad question from several aspects including the customers' perception, various technical aspects, and the related societal aspects. In each case, we
Jokinen, Jani-Pekka +5 more
+7 more sources
The role of integrated shared, demand-responsive transport services in mobility transitions
European Transport StudiesThis paper explores the potential of a novel niche mobility solution, a demand-responsive transport (DRT) service, to address challenges associated with a transition away from car-based transport.
Marianne Ryghaug, Hampus Karlsson
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Espace populations sociétés, 2007 This paper aims to discuss the real and potential outcomes of Demand Responsive Transports (DRT). Those services allow to care for new mobilities that induce complex temporalities.
Elodie Castex, Didier Josselin
doaj +1 more source
Vertical Transportation Demand Response: Cost of Lost Customer Hours [PDF]
2018 15th International Conference on the European Energy Market (EEM), 2018 Vertical transportation systems are designed to enhance the people flow. T he power c onsumption of escalators and elevators depends on applied technology, control strategies and passenger flow. Vertical transports are often e quipped with energy saving technologies and are eligible for demand response (DR).
Tukia, Toni +3 more
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source