Results 51 to 60 of about 37,492 (263)

Why Urban Mass Demand Responsive Transport? [PDF]

2011 IEEE Forum on Integrated and Sustainable Transportation Systems, 2011
In this paper, we argue that a large-scale demand responsive system is the missing element from the spectrum of the urban transport modes. To this end, we provide a comprehensive analysis addressing this broad question from several aspects including the customers' perception, various technical aspects, and the related societal aspects. In each case, we
Jokinen, Jani-Pekka, Sihvola, Teemu, Hyytiä, Esa, Sulonen, Reijo   +5 more
openaire   +3 more sources

Smart Urban Mobility Innovations: A Comprehensive Review and Evaluation

IEEE Access, 2020
Recent smart urban mobility innovations such as intelligent transportation systems, electric vehicles, autonomous vehicles, demand-responsive transportation, shared transportation, and mobility-as-a-service are consistently identified as the panacea to ...
Luke Butler, Tan Yigitcanlar, Alexander Paz   +2 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Data-Driven Bus Route Optimization Algorithm Under Sudden Interruption of Public Transport

IEEE Access, 2022
With the continuous expansion of urban traffic operation scale, public transport emergencies occur from time to time, causing serious traffic jams and potential safety hazards in a short time.
Ruisong Liu, Ning Wang
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Navigating autonomous demand responsive transport: stakeholder perspectives on deployment and adoption challenges

International Journal of Digital Earth
As cities implement intelligent systems and public transportation users seek flexibility, autonomous demand-responsive transport (ADRT) will play an important role in a region’s broader public transportation system.
Fahimeh Golbabaei, Alexander Paz, Tan Yigitcanlar, Jonathan Bunker   +3 more
doaj   +1 more source

A behavioral economic perspective on demand responsive transportation

Transportation Research Interdisciplinary Perspectives
In this article, a utility function framework is developed, serving to determine the demand for an upcoming demand responsive transportation system. A linear’public-good game’ (PGG) model is modified in a way that maximizing the consumer surplus is assumed to determine individual decision-making.
Aljoscha Minnich, Heiko Herbst, Stephan Herminghaus, Thomas Kneib, Benjamin Wacker, Jan Christian Schlüter   +5 more
openaire   +4 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source