Results 61 to 70 of about 2,563,822 (300)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Physical demand but not dexterity is associated with motor flexibility during rapid reaching in healthy young adults [PDF]

, 2015
Healthy humans are able to place light and heavy objects in small and large target locations with remarkable accuracy. Here we examine how dexterity demand and physical demand affect flexibility in joint coordination and end-effector kinematics when ...
Hortobágyi, Tibor, Tibor Hortobàgyi, Bongers, Raoul M.; id_orcid, Hortobagyi, Tibor; id_orcid, Christian Greve (476849), Christian Greve, Bongers, Raoul, Bongers Raoul M., Bongers, Raoul M., Hortobàgyi Tibor, Raoul M. Bongers (476850), Raoul M Bongers, Tibor Hortobàgyi (5663497), Greve Christian, Greve, Christian   +14 more
core   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Changing demand: flexibility of energy practices in households with children (final report) [PDF]

, 2015
This report summarises the findings and recommendations from the ‘Changing Demand: Flexibility of energy practices in households with children’ research project funded by the Consumer Advocacy Panel.
Yolande Strengers, Larissa Nicholls
core  

A Real-World Case Study Towards Net Zero: EV Charger and Heat Pump Integration in End-User Residential Distribution Networks

Energies
The electrification of energy systems is essential for carbon reduction and sustainable energy goals. However, current network asset ratings and the poor thermal efficiency of older buildings pose significant challenges.
Thet Paing Tun, Oguzhan Ceylan, Ioana Pisica   +2 more
doaj   +1 more source

Distribution-Level Flexibility Market for Congestion Management

Energies, 2018
Nowadays, problems facing Distribution System Operators (DSOs) due to demand increase and the wide penetration of renewable energy are usually solved by means of grid reinforcement.
Ayman Esmat, Julio Usaola, María Ángeles Moreno   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Analysis and Quantification of Demand Flexibility for Resilient Distribution Networks: A Systematic Review

IEEE Access
Modern power systems face increasing operational challenges due to the integration of renewable energy sources (RESs) and evolving demand patterns. Demand flexibility (DF) has emerged as a transformative solution by dynamically adjusting electricity ...
Mohamed Massaoudi, Katherine R. Davis, Khandaker Akramul Haque   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source