Results 81 to 90 of about 126,857 (267)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Household demand flexibility during crises: the role of meta-services

Sustainability: Science, Practice, & Policy
As the energy transition accelerates and societies face increasing disruptions, the need for household demand flexibility becomes more critical. This article advances the understanding of demand flexibility through a practice-theoretical perspective ...
Jenny Rinkinen, Kaisa Matschoss
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Electricity Demand Forecasting Based on Flexibility Characterization

Electricity
Electricity demand forecasting is essential for optimizing energy management and planning in microgrids and institutional contexts. The purpose of this article is to demonstrate how flexibility characterization can serve as a structural foundation for ...
Jesús Alexander Osorio-Lázaro, Ricardo Isaza-Ruget, Javier Alveiro Rosero García   +2 more
doaj   +1 more source

Demand Flexibility Management for Buildings-to-Grid Integration with Uncertain Generation

Energies, 2020
We present a Buildings-to-Grid (BtG) integration framework with intermittent wind-power generation and demand flexibility management provided by buildings.
Vahab Rostampour, Thom S. Badings, Jacquelien M. A. Scherpen   +2 more
doaj   +1 more source

Flexibility and the demand for risky assets [PDF]

Economics Letters, 1982
Abstract The fact that reduced flexibility always increases the demand for insurance has led to the belief that reduced flexibility always makes individuals more ‘risk averse’. However, it is quite possible for reduced flexibility to lead to less risk averse behavior in the standard asset demand sense.
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

DFAT: A web-based toolkit for estimating demand flexibility in building-to-grid integration

SoftwareX
Demand Flexibility Assessment Tool (DFAT) is an open source web-based tool that estimates the demand flexibility potential of common control strategies in commercial buildings.
Michael Leong, Medha Mahanta, Clara Yin, Timothy Jairus Garcia, Zach Tan, Anand Krishnan Prakash, Doug Black, Rongxin Yin   +7 more
doaj   +1 more source