Results 71 to 80 of about 126,857 (267)

Analysis and Quantification of Demand Flexibility for Resilient Distribution Networks: A Systematic Review

IEEE Access
Modern power systems face increasing operational challenges due to the integration of renewable energy sources (RESs) and evolving demand patterns. Demand flexibility (DF) has emerged as a transformative solution by dynamically adjusting electricity ...
Mohamed Massaoudi, Katherine R. Davis, Khandaker Akramul Haque   +2 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Recent Advancements in Latent Thermal Energy Storage and Their Applications for HVAC Systems in Commercial and Residential Buildings in Europe—Analysis of Different EU Countries’ Scenarios

Energies
Heating, ventilation, and air-conditioning (HVAC) systems account for the largest share of energy consumption in European Union (EU) buildings, representing approximately 40% of the final energy use and contributing significantly to carbon emissions ...
Belayneh Semahegn Ayalew, Rafał Andrzejczyk   +1 more
doaj   +1 more source

Appliance-Level Flexible Scheduling for Socio-Technical Smart Grid Optimization

IEEE Access, 2020
Participation in residential energy demand response programs requires an active role by consumers. They contribute flexibility in how they use their appliances as the means to adjust energy consumption, and reduce demand peaks, possibly at the expense of
Farzam Fanitabasi, Evangelos Pournaras
doaj   +1 more source

Explanation of Flexibility Manufacturing Role in the World ClassCase study: Saipa automotive group [PDF]

پژوهش‌های مدیریت عمومی, 2016
One of the major business risks in the world-class manufacturing and services firms is the risk of imbalance between supply and demand. To respond to fluctuations in demand, changing the capacity is an expensive strategy that some of organizations adopt ...
hasan Farsijani, ahmad Beklari
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Optimal Scheduling of Integrated Energy Systems Considering Electric Vehicle Charging Patterns and Supply-Demand Flexibility [PDF]

Dianli jianshe
[Objective] To enhance the flexibility and low-carbon performance of integrated energy systems （IES）， this study proposes an optimal scheduling strategy that accounts for various electric vehicle （EV） charging modes and supply-demand flexibility ...
LIU Weimin, XIAO Hui, ZENG Linjun, YAN Qin, GUO Huidong, WU Yongxiao
doaj   +1 more source