Results 111 to 120 of about 63,443 (281)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Design of a Demand-Responsive Transit System
, 2007 This research investigates the feasibility of offering demand-responsive transit (DRT) service to the general public in situations of low demand density. The study region is AC Transit District 2 which consists of the cities of Fremont and Newark, California.We developed a methodology to evaluate operating efficiencies of existing bus lines and line ...
Li, Yuwei +3 more
openaire +1 more source
An American Conversation on the Post-2015 Development Agenda [PDF]
, 2013 In the closing months of 2013, over 1,000 Americans gathered in communities large and small to discuss the world they want in 2030. They came together to answer a call to action from Secretary-General Ban Ki-moon for every UN member state to seek public ...
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Research on Fleet Size of Demand Response Shuttle Bus Based on Minimum Cost Method
Applied SciencesDemand-responsive connector services (DRC) are an important means to improve the current mobility connection problem. In this study, we develop a hybrid model for the minimization of total system cost for demand response shuttle buses, which includes ...
Xianglong Sun, Yucong Zu
doaj +1 more source
Is sea-basing a viable method of providing logistic support to the UK amphibious force? [PDF]
, 2000 Maritime power has traditionally been a central part of the UK’s defence planning and is well suited to supporting a wide range of military operations. The littoral area has always created problems for naval planners as most landings historically have ...
Antill, Peter D. +2 more
core
, 2019 We propose a ridesharing strategy with integrated transit in which a private on-demand mobility service operator may drop off a passenger directly door-to-door, commit to dropping them at a transit station or picking up from a transit station, or to both
Chow, Joseph Y. J. +3 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source