Results 61 to 70 of about 63,551 (239)

Iterated clustering optimization of the split-delivery vehicle routing problem considering passenger walking distance

open access: yesTransportation Research Interdisciplinary Perspectives, 2023
The user-oriented, demand-driven nature of customized shuttle bus (CSB) services forces operators to pay more attention to service quality. However, the bus route planning of CSB and other similar systems in established studies rarely took service ...
Jiangbo Wang   +3 more
doaj   +1 more source

Performance Measures to Assess Resiliency and Efficiency of Transit Systems [PDF]

open access: yes, 2017
Transit agencies are interested in assessing the short-, mid-, and long-term performance of infrastructure with the objective of enhancing resiliency and efficiency.
Bartin, Bekir   +9 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Personalized Demand-Responsive Transit Service [PDF]

open access: yes, 2004
Providing easy access to the public transit service is the goal of the California transit agencies. Many travelers cannot take an express transit because they often cannot park and ride. Smart DRT (demand responsive transit) Feeder is a system that collects transit riders from neighborhoods and takes them to transit stations. This system will use APTS (
Cayford, Randall, Yim, Y. B. Youngbin
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Fixed-Route vs. Demand-Responsive Transport Feeder Services: An Exploratory Study Using an Agent-Based Model

open access: yesJournal of Advanced Transportation, 2022
Feeder transport services are fundamental as first and last-mile connectors of mass rapid transit (MRT). They are especially beneficial in low-demand areas where private transport is usually the main transport mode.
Giovanni Calabrò   +5 more
doaj   +1 more source

Personalized Demand Responsive Transit Systems [PDF]

open access: yes, 2000
An aging population in the US, low-density urban sprawl and the accessibility needs of certain groups (particularly disabled and aged) increasingly point to more flexible demand-responsive transit systems in the future. This paper describes the important aspects of a consumer-oriented Personalized Demand Responsive Transit (PDRT) service.
Yim, Y. B., Khattak, Asad J.
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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