Results 61 to 70 of about 4,096 (259)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Role of Demand-Responsive Transport Systems in Sustainable Urban Mobility: A Systematic Literature Review and Stakeholder Analysis

Engineering Proceedings
On-demand transportation, such as demand-responsive public transit (DRT), is gaining prominence as a mobility service tailored to passengers’ needs, offering flexibility in routes, pick-up/drop-off locations, and timing. This study aims to delve into the
László Buics, Adhie Prayogo, Boglárka Eisingerné Balassa   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Data-Driven Modeling of Demand-Responsive Transit: Evaluating Sustainability Across Urban, Rural, and Intercity Scenarios

Systems
Demand-responsive transit (DRT) is an innovative public transportation model that dynamically adjusts routes based on passengers’ specific demands. While existing studies offer insights into routing, scheduling, and network design, they remain fragmented,
Yunxi Zhang, Linjie Gao, Xu Zhao, Anning Ni   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Optimal Design of Demand-Responsive Feeder Transit Services with Passengers’ Multiple Time Windows and Satisfaction

Future Internet, 2018
This paper presents a mixed-integer linear programming model for demand-responsive feeder transit services to assign vehicles located at different depots to pick up passengers at the demand points and transport them to the rail station.
Bo Sun, Ming Wei, Senlai Zhu
doaj   +1 more source

Personalized Demand Responsive Transit Systems [PDF]

, 2000
An aging population in the US, low-density urban sprawl and the accessibility needs of certain groups (particularly disabled and aged) increasingly point to more flexible demand-responsive transit systems in the future. This paper describes the important aspects of a consumer-oriented Personalized Demand Responsive Transit (PDRT) service.
Yim, Y. B., Khattak, Asad J.
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

An Assessment of Microtransit Impacts on its Substitution and Complementarity with other Modes

Findings
In March of 2022, the Metropolitan Atlanta Rapid Transit Authority, or MARTA, which had previously been a fixed-route system only, implemented a demand-responsive transit system called MARTA Reach.
Maha Ahmad, Lillian Cella, Susan C. Pike, Bailey Affolter, Kari E. Watkins   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source