Results 61 to 70 of about 113,433 (343)

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi   +5 more
wiley   +1 more source

Performance analysis and fleet requirements of automated demand-responsive transport systems as an urban public transport service

open access: yesInternational Journal of Transportation Science and Technology, 2018
The introduction of public transport services by fully automated vehicles can potentially change the way public transit services will be operated, as they allow shifting from rigid scheduled and route-bound services towards flexible, demand-responsive ...
Konstanze Winter   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Is sea-basing a viable method of providing logistic support to the UK amphibious force? [PDF]

open access: yes, 2000
Maritime power has traditionally been a central part of the UK’s defence planning and is well suited to supporting a wide range of military operations. The littoral area has always created problems for naval planners as most landings historically have ...
Antill, Peter D.   +2 more
core  

Flex-Route Transit for Smart Cities: A Reinforcement Learning Approach to Balance Ridership and Performance

open access: yesSmart Cities
A major challenge for modern transit systems relying on traditional fixed-route designs is providing broad accessibility to users. Flex-route transit can enhance accessibility in low-density areas, since it combines the directness of fixed-route transit ...
Joseph Rodriguez   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Economies in U.S. demand responsive transit

open access: yesJournal of Advanced Transportation, 1987
AbstractThis paper develops a neoclassical cost function for demand responsive transit (DRT) system and uses it to test the economies of scale hypothesis. The results show economies of scale and further show that the economies can be explained by speed, local and state subsidies, utilization of seating capacity, fleet utilization and an increase in the
openaire   +1 more source

Feeding Urban Rail Transit: Hybrid Microtransit Network Design Based on Parsimonious Continuum Approach

open access: yesInformation
In recent years, the passenger flow volume of conventional transit in major cities has declined steadily. Ground public transit often suffers from congestion during rush hours caused by frequent stops (e.g., conventional fixed-route buses) or excessively
Qian Ye   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Demand-responsive transit systems in areas with low transport demand of “smart city”

open access: yesTransportation Research Procedia, 2020
Abstract The development of modern telecommunications allows the concept of a “smart city” to increase the flexibility of public transportation significantly and, thus, improve population mobility. In this regard, public transportation represents a demand-responsive transit (DRT) system.
Andrey Gorev   +2 more
openaire   +1 more source

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