Results 111 to 120 of about 39,009 (301)

From mode choice to modal diversion: A new behavioural paradigm and an application to the study of the demand for innovative transport services [PDF]

open access: yes, 2009
We analyse past research efforts that focus on modal diversion in the transport sector, as opposed to the classical mode choice concept, showing the added value of this alternative framework that emerges from the existing scientific literature. The modal
Marco Diana, Diana, Marco
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

A Logit Approach to Study the Attractiveness of DRT Stops Location: The Case Study of Ragusa, Italy

open access: yesFuture Transportation
Demand-Responsive Transport (DRT) services ensure the implementation of more sustainable transport solutions and focuses on the creation of more flexible and personalised public transport systems.
Antonio Russo   +4 more
doaj   +1 more source

Demand Responsive Transport, Equity in Public Transport

open access: yes
Demand Responsive Transport (DRT) emerges as an alternative solution to deliver a cost-effective Public Transport (PT) service, particularly in low-demand areas. DRT is a flexible version of PT, which operates based on passengers' specific demand requests. This approach aims to enhance the core role of PT, which is to provide accessible, efficient, and
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Assessing Accessibility to Regional Hubs Through Integrated DRT–Rail Services: Evidence from a Case Study in Southern Italy

open access: yesUrban Science
Demand-responsive transport (DRT) services are increasingly recognised as an effective solution for enhancing accessibility, particularly in low-demand and peripheral areas.
Antonio Russo   +2 more
doaj   +1 more source

Demand Modelling for Responsive Transport Systems Using Digital Footprints

open access: yes, 2015
Traditionally, travel demand modelling focused on long-term multiple socio-economic scenarios and land-use configurations to estimate the required transport supply. However, the limited number of transportation requests in demand-responsive flexible transport systems require a higher resolution zoning.
Paulo Silva 0002   +3 more
openaire   +2 more sources

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

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