Results 91 to 100 of about 39,009 (301)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Mathematical model of on-demand route formation for public transport based on individual passenger requests in low-density population area

International Journal of Advanced Studies
Background. The organization of public transport routes based on individual passenger requests (on-demand routes) using small-class buses in areas with low population density has become a pressing issue due to the necessity of improving the efficiency of
Svetlana S. Titova, Andrey V. Ostroukh
doaj   +1 more source

Transport à la demande points à points en zone peu dense. Proposition d’une méthode d’optimisation de tournées

Cybergeo, 2007
This paper aims to develop innovative and efficient demand responsive transport in rural and low densities areas (Pays du Doubs Central, Franche-Comté, France).
Thierry Garaix, Didier Josselin, Dominique Feillet, Christian Artigues, Élodie Castex   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The combination of e-bike-sharing and demand-responsive transport systems in rural areas: A case study of Velenje. [PDF]

Res Transp Bus Manag, 2021
Bruzzone F, Scorrano M, Nocera S.
europepmc   +1 more source

Factors explaining urban transport systems in large European cities: A cross-sectional approach [PDF]

The importance of effective and efficient mobility in large cities is becoming essential for planners and citizens due to its impact in terms of social, economic and geographic development.
Daniel Albalate, Germà Bel
core  

Best practice demand-responsive transport (DRT) policy [PDF]

, 2007
People living in regional cities and towns around the world expect governments to deliver reasonable levels of public transport services in their local area.
Logan, Paul
core  

Development of a Demand Responsive Transport system with improvement analysis on conventional public transport: A Case Study for Schorndorf, Germany

, 2017
Demand Responsive Transport (DRT) is a passenger-oriented branch of public transport, which consists of a group of passengers sharing a vehicle with flexible pick-up and drop-off locations and times, according to the passenger preferences.
Anke Sauerlander-Biebl, Hesse, Tobias, Sohr, Alexander, Alexander Sohr, Barrilero Gil, Marta, Sauerländer-Biebl, Anke, Marta Barrilero, Tobias Hesse   +7 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source