Results 101 to 110 of about 39,009 (301)

Rethinking shared mobility: analyzing the commercial sustainability of demand-responsive transport in Dubai

Frontiers in Sustainable Cities
With the rapid pace of urbanization and the subsequent dominance of private vehicle usage, cities are under increasing pressure to offer sustainable alternatives to public transportation.
Utpal Deka, Deepthi Mary Dilip
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Exploring the determinants of autonomous minibus adoption: empirical findings from a demand-based service in Germany

European Transport Research Review
Autonomous on-demand services as part of public transport are discussed to improve public transport substantially. A household survey in Karlsruhe, Germany, was conducted among inhabitants of a residential area where a combined autonomous and on-demand ...
Lukas Barthelmes, Gabriel Wilkes, Martin Kagerbauer, Peter Vortisch   +3 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Analyzing the aspects of organising paratransit services in Vilnius

Transport, 2013
The main objective of the paper is to analyze some aspects of organising new paratransit services in Vilnius. The main presented scientific problem is the creation of a new transportation system integrating it into the existing one. The system in Vilnius
Darius Bazaras, Alina Verseckienė
doaj   +1 more source

The demand for public transport: a practical guide

, 2004
This document reports on the outcome of a collaborative study the objective of which was to produce an up-to-date guidance manual on the factors affecting the demand for public transport for use by public transport operators and planning authorities, and
Titheridge, H, Preston, J, Balcombe, R, Paulley, N., Shires, J., Titheridge, H., Mackett, R., Preston, J.M., Shires, J, Mackett, R, Wardman, M., Wardman, M, White, P., Paulley, N, White, P   +14 more
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Public transport disruption management by collaboration with demand responsive services

, 2020
For large cities, public transport represents the backbone for commuters and thus plays a crucial role for society and for the economy. High-capacity public transport services such as metro and commuter trains are efficient during normal operations but ...
Babicheva, Tatiana,, Jenelius, Erik,, Cebecauer, Matej,, Burghout, Wilco,, Leffler, David,   +4 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Dynamic adaptive policymaking for the sustainable city: The case of automated taxis

International Journal of Transportation Science and Technology, 2017
By 2050, about two-thirds of the world’s people are expected to live in urban areas. But, the economic viability and sustainability of city centers is threatened by problems related to transport, such as pollution, congestion, and parking.
Warren E. Walker, Vincent A.W.J. Marchau
doaj   +1 more source

Some observations on the organisation of demand responsive transport service

, 2001
This paper presents new concepts of Demand Responsive Transport (DRT) service provision emphasising the advantages of route flexibility. The paper reviews briefly the development of DRT services world-wide and then focuses on the new service concepts ...
Nelson, JD, Mageean, JF
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