Results 51 to 60 of about 46,132 (265)

Physics‐Aware Machine‐Learning‐Driven Inverse Design of Broadband Ultra‐Open Acoustic Metamaterials

Advanced Science, EarlyView.
A physics‐aware machine‐learning framework enables inverse design of ultra‐open acoustic silencers by decoupling spectral and radial design spaces. The approach rapidly identifies broadband, compact, and highly ventilated architectures, while revealing hidden linear design rules that link geometry, impedance matching, and acoustic performance.
Zhiwei Yang, Mengyu Li, Xiaohang Xie, Ao Chen, Thomas G. Bifano, Xin Zhang   +5 more
wiley   +1 more source

Autorytety religijne w pedagogice. Uwagi metateoretyczne

Paedagogia Christiana, 2016
Przedmiotem artykułu są funkcje przypisywane w pedagogice kategoriom, twierdzeniom i koncepcjom autorstwa osób uznawanych za autorytety religijne. Niejednokrotnie w tej dyscyplinie wiedzy wykorzystywane są pojęcia i tezy formułowane przez osoby niebędące
Piotr Magier
doaj   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Integrating Morality and Science: Semi-Imperative Evidentialism Paradigm for an Ethical Medical Practice

Philosophies
Evidence-based medicine (EBM) supplies the best available data, yet clinicians still face low-value care, surrogate-driven reversals, and pseudoscientific claims. We propose Semi-Imperative Evidentialism (SIE), a normative framework that links evidential
José Nunes de Alencar, Francisca Rego, Rui Nunes   +2 more
doaj   +1 more source

The “Past Future”. Twenty Years of STS and Technical Universities

Tecnoscienza, 2020
If the public engagement of science and technology has been quickly expanding in the past few decades, the same cannot be said about the presence of STS expertise in the knowledge of scientists, engineers and designers.
Paolo Volonté
doaj   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

Why We Can't Have Our Facts Back

Engaging Science, Technology, and Society, 2018
How do we make the case for “knowledge democracy” in the face of the growing influence of right-wing figures and movements that denounce experts and expertise?
Noortje Marres
doaj   +1 more source

Controllable Cascade Aggregation Ion Programmed Nanomachines and Simple Isolation Enable Tumor‐Derived Small Extracellular Vesicles Detection for Enhanced Breast Cancer Assessment

Advanced Science, EarlyView.
This study developed a convenient, enzyme‐free detection platform based on controllable aggregation ion nanomachines. Its favorable anti‐interference capacity and high sensitivity meet the detection requirements for clinical samples processed via a simple filtration method within 10 min.
Zhihao Zhang, Zijing Liu, Xiangyue Meng, Pengjun Jiang, Jie Qu, Yu Jiang, Binxu Qiu, Jie Chen, Piaopiao Chen   +8 more
wiley   +1 more source

The role of coordinates in border diplomacy: The case of Albania [PDF]

Micro, Macro & Mezzo Geoinformation
This study addresses the essential importance of geodetic coordinates in border diplomacy, focusing on the case of Albania. State borders represent not only geographical divisions, but also sovereignty, national identity, and economic interest.
Anduel Cauli, Pal Nikolli, Oltion Pupi
doaj   +1 more source