Results 61 to 70 of about 234,133 (352)
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
L’émergence d’une toponymie plurielle au Mali
L'Espace Politique, 2008 In Mali, municipalities were created in the context of decentralization. Their creation reveals an original process of toponymic renewal at the local level.
Stéphanie Lima
doaj +1 more source
Advanced Science, EarlyView.Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li +9 more
wiley +1 more source
The global 1989?: the year that changed the world [PDF]
, 2009 As we approach the twentieth anniversary of ‘1989 and all that’, it might be worth ducking for cover. Lest we forget, the year ‘1989’ has become something of a cliché, caught in a sense of its own triumphalism, considered by all and sundry (or at least ...
Lawson, George
core
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Territorial Disputes and Problem of Border Demarcation of USSR (Russia) and China in 1960-1990
Научный диалог, 2017 The article is devoted to problems of Russian-Chinese border demarcation. Russian-Chinese relations, with all its positive dynamics, are characterized by the presence of a number of acute problems, although somewhat moved “by the wayside” because of the ...
A. P. Kostyuchenko
doaj +1 more source
Advanced Science, EarlyView.Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang +3 more
wiley +1 more source
The “Past Future”. Twenty Years of STS and Technical Universities
Tecnoscienza, 2020 If the public engagement of science and technology has been quickly expanding in the past few decades, the same cannot be said about the presence of STS expertise in the knowledge of scientists, engineers and designers.
Paolo Volonté
doaj +1 more source
Technology assessment between risk, uncertainty and ignorance [PDF]
, 2012 The use of most if not all technologies is accompanied by negative side effects, While we may profit from today’s technologies, it is most often future generations who bear most risks.
Hillerbrand, Rafaela
core
Aging effects manifested in the potential energy landscape of a model glass former [PDF]
, 2010 We present molecular dynamics simulations of a model glass-forming liquid (the binary Kob-Anderson Lennard-Jones model) and consider the distributions of inherent energies and metabasins during aging.
Andreas Heuer +7 more
core +3 more sources