Results 61 to 70 of about 61,459 (308)

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

Advanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou   +18 more
wiley   +1 more source

Demarcation, Definition, Art [PDF]

, 2013
The question of how to demarcate science from pseudo-science commands relatively little attention today. In the philosophy of logic, by contrast, the problem of demarcating the logical constants is less skeptically regarded.
Adajian, Thomas
core  

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

Autorytety religijne w pedagogice. Uwagi metateoretyczne

Paedagogia Christiana, 2016
Przedmiotem artykułu są funkcje przypisywane w pedagogice kategoriom, twierdzeniom i koncepcjom autorstwa osób uznawanych za autorytety religijne. Niejednokrotnie w tej dyscyplinie wiedzy wykorzystywane są pojęcia i tezy formułowane przez osoby niebędące
Piotr Magier
doaj   +1 more source

Municipal boundary demarcation in South Africa: processes and effects on governance in traditional rural areas

, 2013
Includes bibliographical references.This research adopts a case study approach to investigate disputes involving municipal boundaries in rural communities under traditional authority.
Nxumalo, Cleotilda
core  

Demarcation problem in philosophy of science

, 2021
Práce se zabývá problematikou demarkace ve filosofii vědy. Cílem práce je představení diskurzu nedávné doby ohledně problematiky demarkačního kritéria. Tato práce si za výchozí bod bere článek Larryho Laudana "The Demise of Demarcation Problem", a jeho ...
Tvrz, Jan
core  

ROS‐Responsive Nanobubbles for Dual‐Enhanced Ultrasound and Magnetic Resonance Imaging of Tumor Oxidative Stress

Advanced Science, EarlyView.
We report the development of biotinylated PEGylated bilirubin‐coated perfluoropentane (bt‐PEG‐BR@PFP) nanobubbles, a novel class of ROS‐activatable and dual‐modality contrast agents that amplify both ultrasound (US) and magnetic resonance imaging (MRI) signals in response to elevated ROS.
Wonsik Jung, Youngju Son, Dong Yun Lee, Youngeun Jeon, Muhammad Asaddudin, Sung‐Hong Park, Sangyong Jon   +6 more
wiley   +1 more source

Integrating Morality and Science: Semi-Imperative Evidentialism Paradigm for an Ethical Medical Practice

Philosophies
Evidence-based medicine (EBM) supplies the best available data, yet clinicians still face low-value care, surrogate-driven reversals, and pseudoscientific claims. We propose Semi-Imperative Evidentialism (SIE), a normative framework that links evidential
José Nunes de Alencar, Francisca Rego, Rui Nunes   +2 more
doaj   +1 more source

RISK REGION. POINTS OF VIEW [PDF]

Riscuri şi Catastrofe, 2016
The paper deals with three fundamental issues related to natural risks. The first issue concerns the definition and characteristics of the risk region.
VICTOR SOROCOVSCHI
doaj