Results 71 to 80 of about 46,132 (265)

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Managing subclinical rhegmatogenous retinal detachment with demarcation laser photocoagulation: A case series

Oman Journal of Ophthalmology
Symptomatic retinal detachment threatening the macula is considered an emergency requiring surgical intervention. However, the management of subclinical rhegmatogenous retinal detachment remains controversial, with differing opinions among clinicians ...
Lalit Verma, Shweta Singh, Avnindra Gupta, Bhanu Priya, Vijay Kumar   +4 more
doaj   +1 more source

Demarcating scientific medicine

Studies in History and Philosophy of Science
Scientific medicine and homeopathy are interesting case studies for the ongoing project of demarcating science from pseudoscience. Much of the demarcation literature formulates abstract criteria for demarcating science from pseudoscience generally. In service of a more localist approach to the demarcation problem, I reconstruct a specific demarcating ...
openaire   +2 more sources

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Demarcating normative political theory from political science – and why it matters methodologically (or cheering for a hybrid empirical–normative methodology in political theory)

Political Research Exchange
Scholars debating the methodology of political theory present arguments regarding the function of political science within/for normative political theory. We suggest a demarcation principle separating the core of normative political theory from political
Nahshon Perez
doaj   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Indigenous sciences are not pseudoscience

Ideas in Ecology and Evolution, 2014
Given how difficult it is to define science, it is surprising how readily many people consider Indigenous sciences to be pseudoscience. I review definitions of indigenous science, as well as science and pseudoscience.
Root Gorelick
doaj  

RISK REGION. POINTS OF VIEW [PDF]

Riscuri şi Catastrofe, 2016
The paper deals with three fundamental issues related to natural risks. The first issue concerns the definition and characteristics of the risk region.
VICTOR SOROCOVSCHI
doaj  

Electrochemical and Thermal Interplay in Blended Cathodes for All Solid‐State Batteries

Advanced Energy Materials, EarlyView.
This work analyzes blended LFP‐NMC cathodes for all solid state batteries, revealing their balanced rate performance and enhanced thermal properties. Operando X‐ray diffraction studies uncovered lithiation gradients and asymmetric charging effects due to kinetic limitations.
Simon Si Ming Ji, Zhuo Li, Abhinand Ayyaswamy, Sascha Kremer, Shintaro Inaba, Ana G. Claus, Dayoung Jun, Se Hwan Park, Moonseong Kim, Bairav S. Vishnugopi, Hui Zhong, Sanjit Ghose, Michael Drakopoulos, Nghia T. Vo, Zhong Zhong, Jürgen Janek, Partha P. Mukherjee, Kelsey B. Hatzell   +17 more
wiley   +1 more source

Electrolyte Interfacial Reactivity Regulates Alloying Anode Pulverization

Advanced Energy Materials, EarlyView.
Electrolyte interfacial reactivity governs the degradation of micrometer‐sized alloying anodes by dictating grain refinement and SEI growth. A high‐reactivity ester‐based electrolyte drives pulverization into fine nanoparticles encapsulated by a thick SEI, forming dense electrodes, whereas a low‐reactivity ether‐based electrolyte enables porous ...
Namhyung Kim, Yaobin Xu, Bharat Gwalani, Won‐Gwang Lim, Matthew R. Fayette, Guosheng Li, Mark H. Engelhard, Peiyuan Gao, Yulan Li, Shenyang Hu, Lili Liu, Jiyu Cai, Zonghai Chen, Md Jasim Uddin, Bhuvaneswari M. Sivakumar, Hsin‐Mei Kao, Zihua Zhu, Seoa Kim, Fredrick Omenya, David Reed, Chongmin Wang, Xiaolin Li   +21 more
wiley   +1 more source