Orthopaedic Surgery, EarlyView.This study found that key hematological parameters showed temporal patterns: hemoglobin, hematocrit, neutrophil percentage, neutrophils, and NLR significantly decreased from days 1 to 5 (all p < 0.001), while lymphocytes and monocytes exhibited biphasic dynamics. Monocytes had a significant interaction with time and fracture type, while lymphocytes and
Yuening Han +8 more
wiley +1 more source
Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies
Psychiatry and Clinical Neurosciences, EarlyView.Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda +4 more
wiley +1 more source
Associations of modified triglyceride-glucose indices with risks of dementia subtypes and brain structure: a prospective cohort study. [PDF]
Front NeurolDuan H, Liu J, Pan X, Huang T, Chen X.
europepmc +1 more source
Oral wound healing in the elderly: Mechanisms, challenges, and innovations
Periodontology 2000, EarlyView.Abstract Objective This narrative synthesizes current knowledge on the biological mechanisms, clinical challenges, and regenerative innovations for optimizing intraoral wound healing in the elderly. Methods Narrative review of preclinical and clinical studies addressing age‐related changes in the four canonical wound‐healing phases (hemostasis ...
Ann M. Decker +7 more
wiley +1 more source
An eye on long‐duration spaceflight: Controversies, countermeasures and challenges
Experimental Physiology, EarlyView.Abstract Space flight‐associated neuroocular syndrome (SANS) is a consequence of long‐duration space flight and is detected in two‐thirds of astronauts. In‐flight, this can cause a change in the refraction of the eyes, requiring graded hypermetropic ‘superfocus adjustable’ glasses, optic nerve head oedema and choroidal folds.
Vincent Wing Sum Ng +1 more
wiley +1 more source
Frontal Lobe and Subregional Volumetric Alterations Across Alzheimer's Disease, Amnestic Mild Cognitive Impairment, and Vascular Dementia: An MRI Volumetry Study. [PDF]
Brain SciStojanoski S +5 more
europepmc +1 more source
The therapeutic role of exercise training during menopause for reducing vascular disease
Experimental Physiology, EarlyView.Abstract Menopause marks a major milestone in female reproductive ageing. It is characterized by the cessation of ovarian function and a concomitant decline in hormones such as oestradiol. Subsequently, females undergoing menopausal transition experience a progressive increase in cardiovascular and cerebrovascular disease risk.
Conan L. H. Shing +4 more
wiley +1 more source
Differential Associations of Lipid Profiles with Dementia and Cardiovascular Disease: Findings from the UK Biobank Cohort. [PDF]
Yonsei Med JLee JH, Heo SJ, Ryu HE, Park B, Kwon YJ.
europepmc +1 more source
Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI
Experimental Physiology, EarlyView.Abstract Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain's demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration ...
Ian D. Driver, Kevin Murphy
wiley +1 more source
Guidelines in Action: Cognitive Outcomes and Blood Pressure Control. [PDF]
StrokeSheibani N +2 more
europepmc +1 more source