Results 121 to 130 of about 1,302,226 (351)
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
The Lancet, 2020 G. Livingston +27 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen +12 more
wiley +1 more source
Alzheimer’s Research & Therapy, 2018 Background Cerebrospinal fluid (CSF) biomarkers are increasingly being used to support a diagnosis of Alzheimer’s disease (AD). Their clinical utility for differentiating AD from non-AD neurodegenerative dementias, such as dementia with Lewy bodies (DLB)
Ross W. Paterson +19 more
doaj +1 more source
SenseCam intervention based on cognitive ctimulation therapy framework for early-stage dementia. [PDF]
, 2011 Estimates suggest that Ireland will have 50,000 people with dementia by 2016 and over 100,000 by 2036. Combined with European total costs estimated in 2005 at €130 billion.
Irving, Kate +2 more
core
Using a Requirements Modelling Language to Co-Design Intelligent Support for People Living with Dementia [PDF]
, 2020 Context and motivation: this research developed a new AI application to support people with dementia to maintain quality of life. Problem: the research explored methods for co-designing models of goals that users of an AI application will seek to achieve.
Lockerbie, J., Maiden, N.
core
A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing
Advanced Science, EarlyView.This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang +17 more
wiley +1 more source
Alzheimer’s Research & Therapy, 2018 Background Processing of degraded speech is a promising model for understanding communication under challenging listening conditions, core auditory deficits and residual capacity for perceptual learning and cerebral plasticity in major dementias. Methods
Chris J. D. Hardy +12 more
doaj +1 more source
Addressing the Spiritual Needs of People Aging with Dementia and/or Lifelong Disabilities [PDF]
, 2018 Educational Objectives 1. Present the need for spiritual care as part of holistic care for people living with dementia and/or lifelong disabilities. 2. Distinguish the difference between spirituality and religion. 3.
Berry, Kathy Fogg
core +1 more source