Results 141 to 150 of about 717,640 (312)
Dementia Specific Services in the Community; Mapping Public and Voluntary Services [PDF]
, 2018 The National Dementia Office (NDO), Health Service Executive (HSE) and the Alzheimer Society of Ireland (ASI) partnered on a project to map dementia-specific community based services nationally.
National Dementia Office +1 more
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Advanced Healthcare Materials, EarlyView.A porous parylene‐coated electrode loaded with dexamethasone was developed to reduce inflammation after cochlear implantation. In guinea pigs, the device provided sustained drug release, maintained biocompatibility, improved auditory brainstem response thresholds, and reduced inflammatory cell infiltration and TNF‐α expression.
Chi‐Chieh Chang +11 more
wiley +1 more source
Alcohol, ageing and dementia: a Scottish perspective
, 2011 There are complex relationships between alcohol use; processes of ageing both social and biological; and cognitive impairment. This paper takes Scotland as a case study to begin to unpick and explore these relationships and their implications for people ...
Louise F. McCabe, McCabe, Louise
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European Journal of Cardiovascular Prevention & Rehabilitation, 2001 AbstractObjectiveDementia is prevalent in older adults and the population is ageing. Many factors have been associated with dementia and anything that may aid the prevention of dementia is of importance.MethodThe literature in this area was evaluated and information relating to the various factors that may impact upon the prevention of dementia is ...
openaire +4 more sources
Advanced Healthcare Materials, EarlyView.Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave +8 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Dementia syndrome affects millions of people in the world, and Alzheimer's disease (AD) is the most common cause. We report the detection of the specific biomarker for AD, p‐tau‐181, from physiological to pathological concentrations in cerebrospinal fluid using an electrolyte‐gated organic transistor biosensor.
Marcello Berto +10 more
wiley +1 more source
World Alzheimer report 2015: the global impact of dementia [PDF]
, 2015 Today, over 46 million people live with dementia worldwide, more than the population of Spain. This number is estimated to increase to 131.5 million by 2050. Dementia also has a huge economic impact. Today, the total estimated worldwide cost of dementia
Martin Prince
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Frontiers in Aging NeuroscienceIntroductionPrevious research has tended to focus on early-life education for dementia risk reduction, yet there are great gains for building cognitive reserve in mid- to later-life through educational interventions.
Eddy Roccati +10 more
doaj +1 more source
Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties
Advanced Science, EarlyView.Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez +16 more
wiley +1 more source
Advanced Science, EarlyView.. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li +15 more
wiley +1 more source