Results 291 to 300 of about 1,302,226 (351)

Understanding the Burden: Exploring Key Factors in Dementia Caregiving in Residential Care Homes. [PDF]

J Nurs Res
Chen YH, Lin LC, Chen PH, Lu IH.
europepmc   +1 more source

Variation in Neurodegeneration‐Linked Brain Regions in Young Adult APOE E4 Carriers With Spina Bifida

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Possible pleiotropic effects of apolipoprotein E4 (APOE E4) in individuals with congenital brain malformations are relatively unknown. Our goal was to determine if neurodegeneration‐linked brain region volumes differ significantly between E4 carriers and noncarriers in young adults with spina bifida (SB). Methods Eleven individuals ( 
Joan M. Jasien, Jacques A. Stout, Mohamad A. Mikati, Robert J. Anderson, Brittany G. Nave, Herbert E. Fuchs, Brian Smith, Alexandra Badea, Jeffrey N. Browndyke   +8 more
wiley   +1 more source

Navigating Everyday as Partners to Persons With Early Dementia: A Scoping Review. [PDF]

Scand J Caring Sci
Bøtchiær MV, Kristensen HK.
europepmc   +1 more source

Bioequivalence of a Donepezil/Memantine 10/20 mg Fixed‐Dose Combination Versus Single‐Component Tablets in Healthy Korean Males

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A fixed‐dose combination (FDC) tablet formulation of donepezil/memantine (10/20 mg) was developed to improve medication compliance in patients with Alzheimer's disease (AD). This study compared the pharmacokinetic (PK) characteristics and safety profiles of an FDC formulation (donepezil/memantine [10/20 mg]) and single components (SCs) of ...
Minkyu Choi, Byung Hak Jin, Do Hoon Keum, Kyoung Hoon Mo, Min Soo Park, Juhwan Lee, Sungjin Park, Choon Ok Kim   +7 more
wiley   +1 more source

A digital programme to prevent falls and improve well-being in people living with dementia in the community: the KOKU-LITE feasibility randomised controlled trial protocol. [PDF]

BMJ Open
Gangannagaripalli J, Vardy E, Stanmore E.   +2 more
europepmc   +1 more source

Population Pharmacokinetic and Exposure‐Response Analysis of the Cognitive Effects of TAK‐071 in Participants With Parkinson Disease and Cognitive Impairment

Clinical Pharmacology in Drug Development, EarlyView.
Abstract TAK‐071 is a novel muscarinic M1 positive allosteric modulator under investigation for the treatment of cognitive impairment and falls associated with Parkinson disease (PD). This study evaluated population pharmacokinetics of TAK‐071 following single (1‐160 mg) and multiple (3‐15 mg once daily) oral‐dose TAK‐071 in 112 healthy participants ...
Hongxia Jia, Axel Facius, Rachel Jennings, Yaming Hang, Jaya Padmanabhan, Niraj M. Shanbhag, Brian T. Harel, Arthur Simen, Wei Yin   +8 more
wiley   +1 more source

How Sodium Dodecyl Sulfate Micelles Affect the Coordination and Peroxidase‐Like Activity of the Hemin–Aβ16 Complex

ChemPlusChem, EarlyView.
The interaction between iron‐heme and amyloid‐β (Aβ) peptides can be strongly influenced by the cellular compartment. The presence of sodium dodecyl sulfate as a lipid‐mimicking system shows a protective role of the membrane by hindering both the formation of the heme–Aβ complex and the peroxidase‐like activity, reducing the accessibility of the lipid ...
Chiara Bacchella, Simone Novellini, Elisa Miotto, Stefania Nicolis, Enrico Monzani, Simone Dell’Acqua   +5 more
wiley   +1 more source

Risk of dementia in Nepal: A cross-sectional survey in mountainous, hilly, and lowland regions. [PDF]

PLoS One
Simkhada B, Thapa Magar S, Simkhada P, Tamang P, Stephenson J.   +4 more
europepmc   +1 more source

Risk of Infections with SGLT2 Inhibitors Versus DPP4 Inhibitors: A Population‐Based Cohort Study Using Antibiotic Dispensing Data

Clinical Pharmacology &Therapeutics, EarlyView.
This study compared the number and cumulative dose of antibiotic dispensings among new users of sodium–glucose cotransporter‐2 (SGLT2) inhibitors and dipeptidyl peptidase‐4 (DPP4) inhibitors following hospital discharge in individuals with type 2 diabetes.
Maria J. Alfonso Arvez, George S. Q. Tan, Sam Wade, Zanfina Ademi, Jenni Ilomäki, J. Simon Bell   +5 more
wiley   +1 more source

Use of cognitive screening among older adults who care for people with dementia: a national survey. [PDF]

Gerontologist
Liu Y, Ye W, Mattke S.
europepmc   +1 more source