Results 71 to 80 of about 1,350,087 (353)

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels

Journal of Neuroinflammation, 2023
Background Alzheimer’s disease (AD) has been associated with immune dysregulation in biomarker and genome-wide association studies (GWAS). GWAS hits include the genes encoding complement regulators clusterin (CLU) and complement receptor 1 (CR1 ...
Aurora Veteleanu, Joshua Stevenson-Hoare, Samuel Keat, Nikoleta Daskoulidou, Henrik Zetterberg, Amanda Heslegrave, Valentina Escott-Price, Julie Williams, Rebecca Sims, Wioleta M. Zelek, Sarah M. Carpanini, Bryan Paul Morgan   +11 more
doaj   +1 more source

Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2019
Importance There are currently no proven treatments to reduce the risk of mild cognitive impairment and dementia. Objective To evaluate the effect of intensive blood pressure control on risk of dementia.
J. Williamson, N. Pajewski, A. Auchus, R. Bryan, G. Chelune, A. Cheung, Maryjo L. Cleveland, L. Coker, Michael G. Crowe, W. Cushman, J. Cutler, C. Davatzikos, L. Desiderio, G. Erus, Lawrence J. Fine, S. Gaussoin, Darrin Harris, Meng-Kang Hsieh, K. Johnson, P. Kimmel, M. Tamura, L. Launer, A. Lerner, Cora E. Lewis, J. Martindale-Adams, C. Moy, I. Nasrallah, L. Nichols, S. Oparil, P. Ogrocki, Mahboob Rahman, S. Rapp, D. Reboussin, M. Rocco, B. Sachs, K. Sink, C. Still, M. Supiano, Joni K. Snyder, V. Wadley, J. Walker, D. Weiner, P. Whelton, Valerie Wilson, N. Woolard, J. Wright, C. Wright   +46 more
semanticscholar   +1 more source

Music playlists for people with dementia: Qualitative evaluation of a guide for caregivers [PDF]

, 2021
Sandra Garrido, Laura Dunne, Catherine Stevens, Esther Chang   +3 more
openalex   +1 more source

Longitudinal Study of Salivary Biomarkers in the Definition of Clinico‐Molecular Progression of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo, Daniele Belvisi, Matteo Costanzo, Claudia Caturano, Francesco Emanuele Bellomi, Carolina Cutrona, Flavia Aiello, Giorgio Leodori, Massimo Marano, Romina Mancinelli, Antonella Conte, Giovanni Fabbrini, Alfredo Berardelli, Giorgio Vivacqua   +13 more
wiley   +1 more source

CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks

Nature Communications
DNA-protein interactions have traditionally been profiled via chromatin immunoprecipitation followed by next-generation sequencing (ChIP-seq). Cleavage Under Targets & Tagmentation (CUT&Tag) is a rapidly expanding technique that enables the profiling of ...
Leyla Abbasova, Paulina Urbanaviciute, Di Hu, Joy N. Ismail, Brian M. Schilder, Alexi Nott, Nathan G. Skene, Sarah J. Marzi   +7 more
doaj   +1 more source

Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer’s disease mice

BMC Anesthesiology, 2018
Background There is increasing interest in whether anesthetic agents affect the risk or progression of Alzheimer’s disease (AD). To mitigate many of the methodological issues encountered in human retrospective cohort studies we have used a transgenic ...
Adele Woodhouse, Carmen Maria Fernandez-Martos, Rachel Alice Kathryn Atkinson, Kelsey Anne Hanson, Jessica Marie Collins, Aidan Ryan O’Mara, Nico Terblanche, Marcus Welby Skinner, James Clement Vickers, Anna Elizabeth King   +9 more
doaj   +1 more source

Human iPSC-derived glia models for the study of neuroinflammation

Journal of Neuroinflammation, 2023
Neuroinflammation is a complex biological process that plays a significant role in various brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory responses in the central nervous system.
Nina Stöberl, Emily Maguire, Elisa Salis, Bethany Shaw, Hazel Hall-Roberts   +4 more
doaj   +1 more source

SenseCam intervention based on cognitive ctimulation therapy framework for early-stage dementia. [PDF]

, 2011
Estimates suggest that Ireland will have 50,000 people with dementia by 2016 and over 100,000 by 2036. Combined with European total costs estimated in 2005 at €130 billion.
Irving, Kate, Piasek, Paulina, Smeaton, Alan F.   +2 more
core  

Nerve Excitability in Asymptomatic Carriers and Amyotrophic Lateral Sclerosis Patients With C9orf72

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We investigated the effects of C9orf72 mutation carriership on peripheral nerve excitability in asymptomatic individuals from families with a history of C9orf72 amyotrophic lateral sclerosis (ALS) and patients. Methods We included 47 asymptomatic individuals from families with a history of C9orf72 ALS, of whom 23 were carriers (C9 ...
Diederik J. L. Stikvoort García, H. Stephan Goedee, Leonard H. van den Berg, Boudewijn T. H. M. Sleutjes   +3 more
wiley   +1 more source