Results 51 to 60 of about 1,119,525 (359)
BMC Geriatrics, 2017 Background Dementia is a life-limiting condition that is increasing in global prevalence in line with population ageing. In this context, it is necessary to accurately measure dementia knowledge across a spectrum of health professional and lay ...
Michael J. Annear +5 more
doaj +1 more source
A critical literature review exploring the challenges of delivering effective palliative care to older people with dementia in the acute hospital setting [PDF]
, 2008 Aim. This paper considers the challenges of delivering effective palliative care to older people with dementia and the possible strategies to overcome barriers to endof-life care in these patients. Background.
Birch, Deborah, Draper, Janet
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
In response to the Health Secretary Jeremy Hunt's plans for a safer 7 day dementia service [PDF]
, 2016 Jeremy Hunt's recent announcement for a safer 7 day dementia service outlines some basic principles to improve dementia care, none of which are new, but are these principles realistic in the current climate of the NHS and does it address the real issues ...
Brooke, Joanne
core
Socioeconomic status as a risk factor for dementia death:individual participant meta-analysis of 86 508 men and women from the UK [PDF]
, 2013 Background Life-course socioeconomic factors may have a role in dementia aetiology but there is a current paucity of studies. Meta-analyses of individual participant data would considerably strengthen this evidence base.
Cox +12 more
core +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Molecular MedicineBackground The neuromuscular junction (NMJ) is the synapse between motor neurons and skeletal muscle and controlls movement. Impaired synaptic transmission and NMJ degeneration has been observed during healthy ageing and is also implicated in several ...
Andrea Salzinger +8 more
doaj +1 more source
A systematic review and meta-analysis on the prevalence of dementia in europe. estimates from the highest-quality studies adopting the dsm iv diagnostic criteria [PDF]
, 2018 BACKGROUND: Dementia, including Alzheimer's disease (AD), is one of the most burdensome medical conditions. Usually, the reviews that aim at calculating the prevalence of dementia include estimates from studies without assessing their methodological ...
Bacigalupo, I +7 more
core +1 more source
Focus, 2015 (Reprinted with permission from Lancet 2015; 386:1698-706).
O'Brien JT, Thomas A
openaire +6 more sources
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source