Results 41 to 50 of about 717,640 (312)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Alzheimer’s Research UK Research Conference 2026

Brain and Neuroscience Advances
On 24–25 February 2026, Alzheimer’s Research UK held its annual research conference at Manchester Central Convention Complex and online. The meeting brought together over 700 researchers spanning molecular biology, data science, clinical trials ...
Elizabeth M. Simzer, Jamie A. Elliott, Soraya Meftah, Sowmya Sekizar, Lauren F. P. Young, James H. Catterson   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Challenges and Lifelines: What Was Important to Family Carers of People With Dementia Accessing the Admiral Nurse Services, a Specialist Family-Centered Dementia Support?

SAGE Open, 2019
Admiral Nurses (ANs), specialists in dementia, provide care management to families affected by dementia. A survey was designed to explore family carers’ views on the care received.
Laura Maio, Julia Botsford, Karen Harrison Dening, Steve Iliffe   +3 more
doaj   +1 more source

Microglia in action: how ageing and injury can change the brain's guardians

Frontiers in Cellular Neuroscience, 2015
Neuroinflammation, the inflammatory response in the CNS, is a major determinant of neuronal function and survival during ageing and disease progression.
Athanasios eLourbopoulos, Ali eErturk, Farida eHellal   +2 more
doaj   +1 more source

Neuroimaging in Dementia [PDF]

Seminars in Neurology, 2008
Although dementia is a clinical diagnosis, neuroimaging often is crucial for proper assessment. Magnetic resonance imaging (MRI) and computed tomography (CT) may identify nondegenerative and potentially treatable causes of dementia. Recent neuroimaging advances, such as the Pittsburgh Compound-B (PIB) ligand for positron emission tomography imaging in ...
Vitali, P, Migliaccio, R, Agosta, F, Rosen, Hj, Geschwind, Md   +4 more
openaire   +3 more sources

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Diffusion tensor imaging analysis along the perivascular space suggests impaired glymphatic clearance in Lewy body dementia subtypes

Alzheimer’s Research & Therapy
Background Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are subtypes of Lewy body dementia (LBD) and overlap in symptoms and pathology.
Naomi Hannaway, Angeliki Zarkali, Rohan Bhome, Ivelina Dobreva, Sabrina Kalam, George E. C. Thomas, Barbara Dymerska, Irene Gorostiaga Belio, Katie Tucker, Amanda Heslegrave, Henrik Zetterberg, Rimona S. Weil   +11 more
doaj   +1 more source

Autophagic and endo-lysosomal dysfunction in neurodegenerative disease

Molecular Brain, 2019
Due to their post-mitotic state, metabolic demands and often large polarised morphology, the function and survival of neurons is dependent on an efficient cellular waste clearance system both for generation of materials for metabolic processes and ...
Bilal R. Malik, Daniel C. Maddison, Gaynor A. Smith, Owen M. Peters   +3 more
doaj   +1 more source

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

Nature Communications, 2021
While polygenic risk scores have been shown to be correlated with disease risk, there is little agreement on how the score should be calculated. Here the authors investigate risk scores for Alzheimer’s disease, finding that the most effective approach ...
Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price   +7 more
doaj   +1 more source