Results 31 to 40 of about 623,078 (311)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Alzheimer’s Research UK Research Conference 2026

Brain and Neuroscience Advances
On 24–25 February 2026, Alzheimer’s Research UK held its annual research conference at Manchester Central Convention Complex and online. The meeting brought together over 700 researchers spanning molecular biology, data science, clinical trials ...
Elizabeth M. Simzer, Jamie A. Elliott, Soraya Meftah, Sowmya Sekizar, Lauren F. P. Young, James H. Catterson   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The impact of location on satisfaction with dementia services amongst people with dementia and their informal carers: a comparative evaluation of a community-based and a clinic-based memory service

, 2007
Background: The development of effective medication for the treatment of Alzheimer's disease led to an expansion in the use of memory clinics ther clinic-based services for the delivery and monitoring of the drugs.
Gibson, Grant, Wattis, John, Timlin, Alison, Curran, Stephen   +3 more
core   +1 more source

Challenges and Lifelines: What Was Important to Family Carers of People With Dementia Accessing the Admiral Nurse Services, a Specialist Family-Centered Dementia Support?

SAGE Open, 2019
Admiral Nurses (ANs), specialists in dementia, provide care management to families affected by dementia. A survey was designed to explore family carers’ views on the care received.
Laura Maio, Julia Botsford, Karen Harrison Dening, Steve Iliffe   +3 more
doaj   +1 more source

Microglia in action: how ageing and injury can change the brain's guardians

Frontiers in Cellular Neuroscience, 2015
Neuroinflammation, the inflammatory response in the CNS, is a major determinant of neuronal function and survival during ageing and disease progression.
Athanasios eLourbopoulos, Ali eErturk, Farida eHellal   +2 more
doaj   +1 more source

Neuroimaging in Dementia [PDF]

Seminars in Neurology, 2008
Although dementia is a clinical diagnosis, neuroimaging often is crucial for proper assessment. Magnetic resonance imaging (MRI) and computed tomography (CT) may identify nondegenerative and potentially treatable causes of dementia. Recent neuroimaging advances, such as the Pittsburgh Compound-B (PIB) ligand for positron emission tomography imaging in ...
Vitali, P, Migliaccio, R, Agosta, F, Rosen, Hj, Geschwind, Md   +4 more
openaire   +3 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Diffusion tensor imaging analysis along the perivascular space suggests impaired glymphatic clearance in Lewy body dementia subtypes

Alzheimer’s Research & Therapy
Background Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are subtypes of Lewy body dementia (LBD) and overlap in symptoms and pathology.
Naomi Hannaway, Angeliki Zarkali, Rohan Bhome, Ivelina Dobreva, Sabrina Kalam, George E. C. Thomas, Barbara Dymerska, Irene Gorostiaga Belio, Katie Tucker, Amanda Heslegrave, Henrik Zetterberg, Rimona S. Weil   +11 more
doaj   +1 more source

Pain in dementia

PAIN Reports, 2020
AbstractThe ageing revolution is changing the composition of our society with more people becoming very old with higher risks for developing both pain and dementia. Pain is normally signaled by verbal communication, which becomes more and more deteriorated in people with dementia.
Achterberg, Wilco, Lautenbacher, Stefan, Husebø, Bettina, Erdal, Ane, Herr, Keela   +4 more
openaire   +7 more sources