Results 31 to 40 of about 1,119,525 (359)
BMC Psychiatry, 2023 Background The Lothian Birth Cohort 1936 (LBC1936) is a longitudinal study of ageing with well-characterised assessments, but until now, it has relied on self-report or proxies for dementia such as cognitive tests. Our aims were twofold: a) to describe a
Donncha S. Mullin +15 more
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Reframing dementia care in Maltese Hospitals [PDF]
, 2016 This commentary addresses the urgent need to improve the care of patients with dementia and cognitive impairment in Maltese hospitals by proposing a number of dementia-friendly hospital-based initiatives.
Scerri, Anthony, Scerri, Charles
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Dementias show differential physiological responses to salient sounds
Frontiers in Behavioral Neuroscience, 2015 Abnormal responsiveness to salient sensory signals is often a prominent feature of dementia diseases, particularly the frontotemporal lobar degenerations, but has been little studied. Here we assessed processing of one important class of salient signals,
Phillip David Fletcher +10 more
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BMJ Open, 2021 Objectives The aim of this study was to establish the impact of dementia education and training on the knowledge, attitudes and confidence of health and social care staff.
Sahdia Parveen +6 more
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Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021 Introduction Containment measures implemented to minimize the spread of coronavirus disease 2019 (COVID‐19) are reported to be negatively affecting mental health, diet, and alcohol consumption.
Larissa Bartlett +7 more
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Diagnosis in vascular dementia, applying ‘Cochrane diagnosis rules’ to ‘dementia diagnostic tools’ [PDF]
, 2017 In this issue of Clinical Science, Biesbroek and colleagues describe recent work on magnetic resonance imaging (MRI)-based cerebral lesion location and its association with cognitive decline.
McCleery, Jenny, Quinn, Terence J.
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Identifying features associated with higher-quality hospital care and shorter length of admission for people with dementia : a mixed-methods study [PDF]
, 2020 Background: Concerns have repeatedly been expressed about the quality of inpatient care that people with dementia receive. Policies and practices have been introduced that aim to improve this, but their impact is unclear.
Burns, Alistair +10 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Microglia in action: how ageing and injury can change the brain's guardians
Frontiers in Cellular Neuroscience, 2015 Neuroinflammation, the inflammatory response in the CNS, is a major determinant of neuronal function and survival during ageing and disease progression.
Athanasios eLourbopoulos +2 more
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Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
Nature Communications, 2021 While polygenic risk scores have been shown to be correlated with disease risk, there is little agreement on how the score should be calculated. Here the authors investigate risk scores for Alzheimer’s disease, finding that the most effective approach ...
Ganna Leonenko +7 more
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