Results 31 to 40 of about 717,640 (312)

Physiological phenotyping of dementias using emotional sounds

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015
Introduction Emotional behavioral disturbances are hallmarks of many dementias but their pathophysiology is poorly understood. Here we addressed this issue using the paradigm of emotionally salient sounds.
Phillip D. Fletcher, Jennifer M. Nicholas, Timothy J. Shakespeare, Laura E. Downey, Hannah L. Golden, Jennifer L. Agustus, Camilla N. Clark, Catherine J. Mummery, Jonathan M. Schott, Sebastian J. Crutch, Jason D. Warren   +10 more
doaj   +1 more source

‘We do things together’. A case study of ‘couplehood’ in dementia [PDF]

, 2005
The value of the single case study is well established in dementia care with the seminal contributions of Alzheimer and Kitwood being based on the study of individuals.
Hellström, Ingrid, Lundh, Ulla, Nolan, Mike, Hellström, Ingrid,, Lundh, Ulla,, Nolan, Mike,   +5 more
core   +1 more source

Drawn from life: Cocreating narrative and graphic vignettes of lived experience with people affected by dementia

Health Expectations, 2021
Background The growing literature on Patient and Public Involvement and Engagement (PPIE) and dementia identifies specific problems related to the influence that involvement has on research outcomes, over‐reliance on family members as proxies and lack of
Andrea Capstick, Alison Dennison, Jan Oyebode, Lesley Healy, Claire Surr, Sahdia Parveen, Cara Sass, Michelle Drury   +7 more
doaj   +1 more source

Activation of NMDA receptors in brain endothelial cells increases transcellular permeability

Fluids and Barriers of the CNS, 2022
Neurovascular coupling is a precise mechanism that induces increased blood flow to activated brain regions, thereby providing oxygen and glucose.
Kyu-Sung Kim, Min Tae Jeon, Eun Seon Kim, Chan Hee Lee, Do-Geun Kim   +4 more
doaj   +1 more source

Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience [PDF]

, 2008
Background: Dementia results from heterogeneous diseases of the brain. Mixed disease forms are increasingly recognized. Methods: We performed a survey within brain banks of BrainNet Europe to estimate the proportion of mixed disease forms underlying ...
Gelpi, Ellen, Kretzschmar H, Alafuzoff, Irina, Alafuzoff I, Budka H., Nagy, Zoltan, Seilhean, Danielle, Ferrer I, Arzberger, Thomas, Al-Sarraj, Safa, Gelpi E, Kovacs, Gabor G., Kretzschmar, Hans, Soininen, Hilkka, Troakes, Claire, Nagy Z, Capellari, Sabina, Seilhean D, Kövari V, Budka, Herbert, Al Sarraj S, Troakes C, Alafuzoff, Irina,, Arzberger T, Ferrer, Isidro, Bogdanovic, Nenad, Bogdanovic N, Kovari, Viktor, Soininen H, Parchi, Piero, Kovacs GG   +30 more
core   +1 more source

The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies

Experimental and Molecular Medicine, 2020
Neurodegenerative disorders: Spread of misfolded protein aggregates Further research is needed to determine how an aggregate-forming protein common to several neurodegenerative disorders propagates throughout the brain.
Myungjin Jo, Shinrye Lee, Yu-Mi Jeon, Seyeon Kim, Younghwi Kwon, Hyung-Jun Kim   +5 more
doaj   +1 more source

Identifying dementia using medical data linkage in a longitudinal cohort study: Lothian Birth Cohort 1936

BMC Psychiatry, 2023
Background The Lothian Birth Cohort 1936 (LBC1936) is a longitudinal study of ageing with well-characterised assessments, but until now, it has relied on self-report or proxies for dementia such as cognitive tests. Our aims were twofold: a) to describe a
Donncha S. Mullin, Lucy E. Stirland, Emily Buchanan, Catherine-Anne Convery, Simon R. Cox, Ian J. Deary, Cinzia Giuntoli, Holly Greer, Danielle Page, Elizabeth Robertson, Susan D. Shenkin, Anna Szalek, Adele Taylor, Georgina Weatherdon, Tim Wilkinson, Tom C. Russ   +15 more
doaj   +1 more source

Dementias show differential physiological responses to salient sounds

Frontiers in Behavioral Neuroscience, 2015
Abnormal responsiveness to salient sensory signals is often a prominent feature of dementia diseases, particularly the frontotemporal lobar degenerations, but has been little studied. Here we assessed processing of one important class of salient signals,
Phillip David Fletcher, Jennifer eNicholas, Timothy J Shakespeare, Laura eDowney, Hannah eGolden, Jennifer L Agustus, Camilla eClark, Cath eMummery, Jonathan eSchott, Sebastian eCrutch, Jason eWarren   +10 more
doaj   +1 more source

Impact of dementia education and training on health and social care staff knowledge, attitudes and confidence: a cross-sectional study

BMJ Open, 2021
Objectives The aim of this study was to establish the impact of dementia education and training on the knowledge, attitudes and confidence of health and social care staff.
Sahdia Parveen, Jan R Oyebode, Sarah Jane Smith, Cara Sass, Andrea Capstick, Alison Dennison, Claire A Surr   +6 more
doaj   +1 more source

Change in modifiable dementia risk factors during COVID‐19 lockdown: The experience of over 50s in Tasmania, Australia

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Introduction Containment measures implemented to minimize the spread of coronavirus disease 2019 (COVID‐19) are reported to be negatively affecting mental health, diet, and alcohol consumption.
Larissa Bartlett, James J. R. Brady, Maree Farrow, Sarang Kim, Aidan Bindoff, Hannah Fair, James C. Vickers, Duncan Sinclair   +7 more
doaj   +1 more source