Results 191 to 200 of about 53,955 (247)

Mitochondria and Epigenetic Regulation: Bidirectional Crosstalk and Emerging Mitochondria-Targeted Degron Tools. [PDF]

Cells
Xu Y, Jian X, Shi L, Shock LS, Chen L, Chow LT, Wang H.   +6 more
europepmc   +1 more source

Illuminating what lies in darkness: Circadian regulation of hypocotyl growth in Arabidopsis via ELF3 recruitment of demethylases. [PDF]

Plant Cell
Robinson J.
europepmc   +1 more source

Selective small molecule targeting of KDM4 as a therapeutic strategy to reduce proliferation of acute myeloid leukaemia. [PDF]

Br J Haematol
Monaghan L, Bunschoten RP, Bittencourt-Silvestre J, Park T, Gannon S, Pirvan PA, Hoose A, Wheadon H, Liskamp RMJ, Huang X, Jørgensen HG.   +10 more
europepmc   +1 more source

High-resolution HIV-1 m⁶A epitranscriptome reveals isoform-dependent methylation clusters and unique 2-LTR transcript modifications. [PDF]

NAR Genom Bioinform
Naquin D, Blanchet S, van Dijk E, Bertrand L, Grégoire S, Ramirez BC, Ouazahrou R, Jaszczyszyn Y, Moris A, Thermes C, Hernandez C, Namy O.   +11 more
europepmc   +1 more source

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When Is a Demethylase Not a Demethylase?

Science, 2011
The histone lysine demethylase JARID1a has demethylase-independent function in the circadian clock.
openaire   +2 more sources

Inhibitors of histone demethylases

Bioorganic & Medicinal Chemistry, 2011
Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared.
Lohse, Brian, Kristensen, Jesper L, Kristensen, Line H, Agger, Karl, Helin, Kristian, Gajhede, Michael, Clausen, Rasmus P   +6 more
openaire   +3 more sources

JmjC Lysine Demethylases

2015
Among the most fundamental questions in the regulation of gene expression in mammals is how epigenetic methylation patterns of histone lysine residues are established, recognized and erased. This chapter reviews recent studies on, and discusses the resulting biochemical and structural insights into, the Jumonji C (JmjC)-containing lysine demethylases ...
Xiaodong Cheng, Raymond C. Trievel
openaire   +1 more source

In Vitro Histone Demethylase Assays

2022
Dynamic histone methylation regulates gene activation and repression. It is involved in proliferation, differentiation, lineage specification, and development. Histone demethylase assays are invaluable in studying histone demethylation substrate recognition, kinetics, regulation, and inhibition by small molecules, many of which are potential ...
openaire   +2 more sources