Results 51 to 60 of about 1,477,829 (339)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Harmonizing the fundamental principles of economy and moral philosophy

Focus on Research in Contemporary Economics, 2020
In its simplest form, morality refers to the value judgments that we define as "good" or "right" in human relations. Here, questions arise such as "what is understood from good? what is the criteria?, and what is good for whom?".
Cemil Ertuğrul, Ebru Unat
doaj  

Developmental Democracy in Africa: A Review [PDF]

, 2018
Democracy is one of the virtues we ache for, as many now observe an undemocratic society as a savage society. Richard L. Sklar built up a hypothesis called developmental democracy in which he opines that democracy will essentially prompts the improvement
Bassey, Samuel Akpan, Udoudom, Mfonobong David   +1 more
core  

Rethinking democracy promotion [PDF]

, 2012
Despite the fact that democracy promotion is a major part of liberal foreign policies, the discipline of International Relations has not paid much systematic attention to it.
Acemoglu, BEATE JAHN, Bhagwati, Cammack, Carothers, Carothers, Carothers, Cavell, Chirot, Cowles, Dahl, De Zeeuw, Diamond, Diamond, Donnelly, Dunn, Finkel, Fukuyama, Gray, Guilhot, Inayatullah, Ivison, Jahn, Laslett, Latham, Locke, Locke, Locke, Magen, Marks, May, McNally, Michael, Packenham, Peceny, Plattner, Robinson, Rose, Schmitter, Schraeder, Smith, Smith, Talavera, Tilly, Tilly, Tilly, Tuck, Tully, Tully, Wehler   +49 more
core   +1 more source

An open democracy [PDF]

Molecular Cancer, 2007
Sovereign power is retained and shared by the citizens of a country. Using electoral tools, governing structures are formed to ensure protection of national interests. As with any institution, proper control of the government guarantees its adherence to the tasks delegated to it by its citizens.
Christian Schmidt, Christian Schmidt, Shawn Mathur   +2 more
openaire   +4 more sources

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

China's e-democracy in information age [PDF]

, 2012
E-democracy is a new type of democracy in Information Age. At first, the paper discusses the definitions of democracy and e-democracy, and then the paper analyzes the advantages and problems of E-democracy in China.
Liu, Yigong
core  

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Democracy and credit [PDF]

Journal of Financial Economics, 2020
Abstract Does democratization reduce the cost of credit? Using global syndicated loan data from 1984 to 2014, we find that democratization has a sizable negative effect on loan spreads: a 1-point increase in the zero-to-ten Polity IV index of democracy shaves at least 19 basis points off spreads, but likely more.
Iftekhar Hasan, Iftekhar Hasan, Iftekhar Hasan, Manthos D. Delis, Steven Ongena, Steven Ongena, Steven Ongena   +6 more
openaire   +3 more sources

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source