Results 31 to 40 of about 10,948 (258)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Organizacija inžinjerijskih radova pri rušenju deonice puta / Organization of engineering works during demolition of a road section / Организация инженерных работ по демонтажу участков дорог

open access: yesVojnotehnički Glasnik, 2016
Prilikom upotrebe minsko-eksplozivnih sredstava za rušenje elemenata, materijala i objekata jako je bitna organizacija izvođenja radova prilikom pripreme i u toku izvođenja samog rušenja.
Nenad V. Kovačević
doaj   +1 more source

The old town house in Obrenovac [PDF]

open access: yesNasleđe, 2015
The paper outlines the development of the commercial quarter of Obrenovac because it made possible the emergence of a formally elaborate town house in the style of Balkan architecture.
Živković Nada
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Representações da violência no cinema de Pedro Costa

open access: yesStudia Iberystyczne, 2016
THE REPRESENTATIONS OF VIOLENCE IN THE CINEMA OF PEDRO COSTA This article aims to reflect about the violent reality represented by the Portuguese film director Pedro Costa in the Letters from Fontainhas trilogy.
Guilherme Figueiredo
doaj   +1 more source

An Overview about the Current Situation on C&D Waste Management in Italy: Achievements and Challenges

open access: yesBuildings, 2021
The disposal volume of material for Construction and Demolition in Europe is increasing each year, that the European Union has decided to take control of the matter unifying practices and goals to achieve. This article analyses how waste management works
Javier Cárcel-Carrasco   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Towards urban LCA: examining densification alternatives for a residential neighbourhood

open access: yesBuildings & Cities
This paper explores the environmental impacts of retaining or replacing buildings by extending the consequential replacement framework (CRF) for life-cycle assessment (LCA) from individual buildings towards the urban scale. It addresses a gap in previous
Malin Moisio   +7 more
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

open access: yesFEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

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