Results 41 to 50 of about 10,870 (259)

The masonry behaviour under contact detonation [PDF]

Urbanism. Arhitectura. Constructii, 2017
Breaching in masonry wall as a process of quick intervention of special forces in emergency cases, may require the use of explosive charges. In order to maximize the explosive effects on the wall and to minimize the shock wave and fragments propulsion ...
Marin Lupoae, Francois Windeck, David Breaud, Cătălin Baciu   +3 more
doaj  

Code for a safe and sustainable performance of demolition and dismantling

Materiales de Construccion, 2012
Demolition and dismantling have been traditionally considered an obstacle to overcome before starting new constructions, up to the inclusion in the industry of the concept of sustainable development, which implies impacts minimization, recovery ...
J. González, M. B. Díaz, R. Rodríguez
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

An Overview about the Current Situation on C&D Waste Management in Italy: Achievements and Challenges

Buildings, 2021
The disposal volume of material for Construction and Demolition in Europe is increasing each year, that the European Union has decided to take control of the matter unifying practices and goals to achieve. This article analyses how waste management works
Javier Cárcel-Carrasco, Elisa Peñalvo-López, Manuel Pascual-Guillamón, Fidel Salas-Vicente   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Drivers of Housing Demolition Decision Making and the Impact on Timber Waste Management

Construction Economics and Building, 2011
The study investigates housing demolition and timber waste recovery – with the aim to identify ways of improving recovery. Using case studies the research focused on demolisher decision making, their onsite processes and the associated network of ...
Perry John Forsythe
doaj   +1 more source

Kralupy u Chomutova: Demolice obce kvůli rozšiřování těžby uhlí

Historická sociologie, 2020
The article is focused on the story of the village Kralupy u Chomutova, which was demolished in the 1970s due to the expanding coal mining. It monitors the process of demolition and response of its citizens.
Jana Vitíková
doaj   +1 more source