Results 1 to 10 of about 90,516 (299)

A Novel Family with Demyelinating Charcot–Marie–Tooth Disease Caused by a Mutation in the PMP2 Gene: A Case Series of Nine Patients and a Brief Review of the Literature

Children, 2023
Introduction: Charcot–Marie–Tooth (CMT) is a group of inherited peripheral neuropathies characterized by wide genotypic and phenotypic variability. The onset is typically in childhood, and the most frequent clinical manifestations are predominantly ...
Margherita Baga, Susanna Rizzi, Carlotta Spagnoli, Daniele Frattini, Francesco Pisani, Carlo Fusco   +5 more
doaj   +1 more source

New Insight into the Possible Roles of L-Carnitine in a Rat Model of Multiple Sclerosis

Brain Sciences, 2023
Objective: We investigated the effect of L-carnitine (LC) on cuprizone (Cup) demyelinating rat model and its possible underlying mechanisms. Methods: Thirty male Sprague–Dawley (SD) rats were randomly allocated to three groups: the normal control group ...
Sally M. Safwat, Moutasem Salih Aboonq, Mahmoud El Tohamy, Moaz Mojaddidi, Saeed Awad M. Al-Qahtani, Madaniah Omar Zakari, Ahmed A. ElGendy, Abdelaziz M. Hussein   +7 more
doaj   +1 more source

Brainstem syndrome at onset is related to an early MS diagnosis in Peru: A national referral center cohort

Heliyon, 2021
Background: MS is unpredictable regarding clinical symptoms; however, certain symptoms represent the preferred localization of white matter lesions such as brainstem, spinal cord; or optic nerve.
César Caparó-Zamalloa, Sheila Castro-Suarez, Jaqueline Cortez-Escalante, Wilfor Aguirre-Quispe, Erik Guevara-Silva, Victor Osorio-Marcatinco, María Meza-Vega   +6 more
doaj   +1 more source

Immunopathology of Tumefactive Demyelinating Lesions-From Idiopathic to Drug-Related Cases

Frontiers in Neurology, 2022
Tumefactive demyelinating lesions (TDL) represent a diagnostic dilemma for clinicians, and in rare atypical cases a collaboration of a neuroradiologist, a neurologist, and a neuropathologist is warranted for accurate diagnosis.
Aigli G. Vakrakou, Maria-Evgenia Brinia, Ioanna Svolaki, Theodore Argyrakos, Leonidas Stefanis, Constantinos Kilidireas   +5 more
doaj   +1 more source

Recurrent Fulminant Tumefactive Demyelination With Marburg-Like Features and Atypical Presentation: Therapeutic Dilemmas and Review of Literature

Frontiers in Neurology, 2020
Atypical forms of demyelinating diseases with tumor-like lesions and aggressive course represent a diagnostic and therapeutic challenge for neurologists.
Aigli G. Vakrakou, Dimitrios Tzanetakos, Theodore Argyrakos, Georgios Koutsis, Maria-Eleptheria Evangelopoulos, Elisabeth Andreadou, Maria Anagnostouli, Marianthi Breza, John S. Tzartos, Elias Gialafos, Antonios N. Dimitrakopoulos, Georgios Velonakis, Panagiotis Toulas, Leonidas Stefanis, Constantinos Kilidireas   +14 more
doaj   +1 more source

Optic neuritis in CD59 deficiency: an extremely rare presentation

The Turkish Journal of Pediatrics, 2022
Background. CD59 is the principal cell inhibitor of complement membrane attack on cells. Stroke, peripheral neuropathy, and recurrent central nervous system attacks have been reported in patients with inherited CD59 deficiency.
Çağatay Günay, Elvan Yardım, Elif Yaşar, Ayse Semra Hız-Kurul, Gamze Sarıkaya Uzan, Taylan Öztürk, Aylin Yaman, Uluç Yiş   +7 more
doaj   +1 more source

Heterogeneity of Baló’s concentric sclerosis: a study of eight cases with different therapeutic concepts

BMC Neurology, 2020
Background Baló’s Concentric Sclerosis (BCS) is a rare heterogeneous demyelinating disease with a variety of phenotypes on Magnetic Resonance Imaging (MRI).
D. Tzanetakos, A. G. Vakrakou, J. S. Tzartos, G. Velonakis, M. E. Evangelopoulos, M. Anagnostouli, G. Koutsis, E. Dardiotis, E. Karavasilis, P. Toulas, L. Stefanis, C. Kilidireas   +11 more
doaj   +1 more source

Clinical Evaluation of Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease- A Case Series [PDF]

Journal of Clinical and Diagnostic Research, 2022
In recent years, there has been lot of research on Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG) associated disease. It’s clinical phenotype overlaps with Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorder (NMOSD), however many ...
Rahul Gupta, Ramji Sharma, Deepali Sharma   +2 more
doaj   +1 more source

Transition clinic in pediatric onset multiple sclerosis: Opinions of pediatric neurologists and neurologists

Medicine Science, 2022
Multiple sclerosis (MS) is rare in children compared to adults. The management of pediatric onset MS (POMS) differs from adult disease, and the appraoch of pediatric neurologists and neurologists can also diverge in practice.We conducted a survey among ...
Ismail Solmaz
doaj   +1 more source

Working up a child with demyelinating optic neuritis: Striking a balance!

Oman Journal of Ophthalmology, 2021
Pediatric optic neuritis (PON) is one of the commonest causes of acute vision loss in children. Although it might often be postinfectious or postvaccination, recent understanding and available evidence suggest that it can be the first manifestation of a ...
Virender Sachdeva, Ramesh Kekunnaya
doaj   +1 more source