Results 91 to 100 of about 90,516 (299)

Electrodiagnostic evaluation in diabetes mellitus: A study based on case series in 72 diabetic patients

Journal of Family Medicine and Primary Care
Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes; so, a nerve conduction study (NCS) is conducted to detect the type of neuropathy that is present. To discuss the NCS findings in diabetic patients. An observational
Suchitra Dube, Sandip M. Hulke, Avinash E. Thakare, Sagar Khadanga, Santosh L. Wakode, Rajay N. Bharshankar, Abhijit Pakhare   +6 more
doaj   +1 more source

Anti-NMDAR Antibodies in Demyelinating Diseases

, 2017
Introduction: Antibodies against N-methyl D-aspartate receptor (anti-NMDAR) are directly pathogenic autoantibodies associated with encephalitis. Cases reporting the presence of anti-NMDAR antibodies associated with a demyelinating disease have been ...
Elisak, M., Marusic, P., Liskova, P., Ivana Štětkářová, Krysl, David,, Petr Marusič, Hanzalova, J., Meluzinova, E., I. Doležalová, Stetkarova, I., Martin Elišák, J. Hanzalová, Petra Lišková, Eva Meluzínová, David Krýsl, Dolezalova, I.   +15 more
core   +1 more source

Predicting relapse in demyelinating diseases in children [PDF]

, 2021
Introduction. Predicting relapse in acute demyelinating episode (ADE) in children is an urgent problem, since progressive demyelinating diseases are associated with the risk of disability and cognitive impairment.Введение.
Невмержицкая, К. С., Nevmerzhitskaya, K. S., Sergeeva, M. V., Сергеева, М. В., Волкова, Л. И., Volkova, L. I.   +5 more
core  

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Autoantibodies to tetraspanins (CD9, CD81 and CD82) in demyelinating diseases

, 2016
Tetraspanin family proteins, CD9, CD81 and CD82 are expressed in the oligodendrocytes and Schwann cells. We investigated autoantibodies to tetraspanin proteins in patients with demyelinating diseases.
Umapathi, T., Shahrizaila, N., Paul, F., Yuki, N., Miyaji, K.   +4 more
core   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Evaluation of Revised Diagnostic Definition of MS

Pediatric Neurology Briefs, 2014
Investigators at Erasmus MC, Rotterdam, The Netherlands, evaluated the 2012 revised IPMSSG consensus definitions in a cohort of children with acquired demyelinating syndromes (ADS) prospectively followed for 2 years from Jan 2007.
J Gordon Millichap, John J Millichap
doaj   +1 more source

Electrodiagnosis of demyelinating neuropathies.

, 2000
The inflammatory demyelinating neuropathies constitute a significant proportion of the acquired polyneuropathies. Major progress in finding the causes and in the treatment of these neuropathies has been made over the last decade.
Jacquerye, P., Piéret, F, Van den Bergh, Peter   +2 more
core  

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source