Results 81 to 90 of about 90,516 (299)

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu   +10 more
wiley   +1 more source

Pruritus in Autoimmune Demyelinating Diseases of the Central Nervous System: A Review

open access: yesAllergies
Pruritus (itching) is an underrecognized but often debilitating symptom in patients with central nervous system (CNS) demyelinating diseases, including multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD).
Christian Messina   +1 more
doaj   +1 more source

Inflammatory Demyelinating Polyradiculopathy

open access: yes, 1998
A clinical and electrodiagnostic, retrospective study of 43 children with acute inflammatory demyelinating polyradiculopathy (AIDP) is reported from the Service de Neuropediatrie, Hopital de Bicetre ...
J Gordon Millichap
core   +1 more source

Chronic Acquired Demyelinating Polyneuropathy following Renal Transplantation [PDF]

open access: yes, 2013
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The clinical, laboratory, and treatment findings of a patient with chronic acquired demyelinating polyneuropathy (CADP ...
Stuart Orsher, D. S. Younger
core   +1 more source

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello   +10 more
wiley   +1 more source

Subacute Demyelinating Polyneuropathy

open access: yes, 2005
The electroclinical characteristics of 5 children (ages 4-13 years) with subacute inflammatory demyelinating polyneuropathy (SIDP) are reported from the Royal Children’s Hospital, Victoria ...
J Gordon Millichap
core   +1 more source

Macrophages and Autoantibodies in Demyelinating Diseases

open access: yes, 2021
Myelin phagocytosis by macrophages has been an essential feature of demyelinating diseases in the central and peripheral nervous systems, including Guillain–Barré syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and multiple ...
Masahisa Katsuno, Haruki Koike
core   +1 more source

Destructive lesions in demyelinating disease

open access: yes, 1991
Three cases are presented in which clinical and radiological features suggested the diagnosis of glioma but surgical biopsy revealed a demyelinating process, with tissue destruction and cyst formation in two.
Kermode, A.G.   +12 more
core   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

open access: yesArthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci   +25 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

open access: yesAdvanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave   +8 more
wiley   +1 more source

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