Results 231 to 240 of about 90,516 (299)

The Emerging Role of UCHL1 in Neurological and Musculoskeletal Diseases

Immunology &Cell Biology, Volume 104, Issue 8, Page 783-793, September 2026.
UCHL1‐associated pathology. The pathological role of UCHL1 in multisystem diseases, including cancer, neurological, musculoskeletal and cardiovascular disorders. ABSTRACT Ubiquitin C‐terminal hydrolase L1 (UCHL1) is a highly conserved deubiquitinating enzyme that has transitioned from being viewed as a “brain‐specific” protein to a global regulator of ...
Ru Feng, Xiu Zhong, Jianjun Li, Adrian A. Achuthan   +3 more
wiley   +1 more source

The Therapeutic Potential of Purmorphamine Across Disease Models

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Purmorphamine (PUR) is a trisubstituted purine compound that selectively activates Smoothened receptor, thereby initiating Sonic Hedgehog (Shh) signalling—a pathway critical for embryonic patterning, neuronal specification and tissue regeneration across multiple organ systems. Dysregulation of Shh signalling has been implicated in degenerative
Ashis Dhar, Ahnaf Dil Sharar, Saikarthik Papisetty, Mohammad Bydon, F. M. Moinuddin   +4 more
wiley   +1 more source

The Electrophysiology of Disease Remission in Chronic Inflammatory Demyelinating Polyneuropathy. [PDF]

Eur J Neurol
Rajabally YA, Freiha J, Iqbal R, Allen D, Osman C.   +4 more
europepmc   +1 more source

Long‐Term Safety and Efficacy of Efgartigimod PH20 in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: ADHERE/ADHERE+ Trial Interim Analysis

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Background and Aims In ADHERE, subcutaneous efgartigimod PH20 (1000 mg once weekly) was effective and well tolerated in participants with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). ADHERE+ is an open‐label extension of ADHERE assessing long‐term safety and efficacy. Methods Eligible participants from ADHERE run‐in period
Jeffrey A. Allen, Geoffrey Istas, Satoshi Kuwabara, Trevor Mole, Luis Querol, Simon Rinaldi, Mark Stettner, Benjamin Van Hoorick, Richard A. Lewis   +8 more
wiley   +1 more source

Concomitant Cervical Spondylotic Myelopathy and Transverse Myelitis Managed With C4-C6 Anterior Cervical Discectomy and Fusion. [PDF]

Cureus
Bridges M, Hamade AJ, Gharib H, Patel NM.   +3 more
europepmc   +1 more source

Diffuse high-grade glioma with gliomatosis cerebri pattern mimicking symmetric white matter disease. [PDF]

Radiol Case Rep
Abouchiba S, Ennasery Z, Ouazzani H, Chaouche I, Akammar A, El Bouardi N, Haloua M, Alami B, Lamrani MYA, Boubbou M, Maaroufi M.   +10 more
europepmc   +1 more source

Dynamics of Myelin-Specific T-Cell Repertoires Mirror Disease Activity and Central Nervous System Trafficking in Multiple Sclerosis. [PDF]

Int J Mol Sci
Di Sante G, Bianco A, Lucchini M, Stabile AM, Pistilli A, Bisurgi M, Cicia A, Bartolini D, Ingrosso L, Rende M, Geloso MC, Rolla S, Ria F, Mirabella M.   +13 more
europepmc   +1 more source

Intractable hiccups as a brainstem red flag: demyelinating disorders with emphasis on neuromyelitis optica spectrum disorder and area postrema syndrome. [PDF]

Neurol Sci
Eliaçık S.
europepmc   +1 more source

Autonomic Nervous System Phenotyping Across Chronic Demyelinating Peripheral Neuropathies: A Comparative Study. [PDF]

J Peripher Nerv Syst
Bjelica B, Todorovic T, Bozovic I, Palibrk A, Jankovic V, Basta I, Peric S.   +6 more
europepmc   +1 more source

Outcome measurement in GNAO1‐related disorder: Balancing global severity and domain‐specific change

Developmental Medicine &Child Neurology, Volume 68, Issue 9, Page 1182-1183, September 2026.
Jana Domínguez‐Carral, Juan Darío Ortigoza‐Escobar   +1 more
wiley   +1 more source