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Annals of Diagnostic Pathology, 2002
Demyelinating disease presenting as a solitary contrast-enhancing mass poses a diagnostic challenge for both radiologists and surgical pathologists. We report the cases of two female patients, aged 23 and 37 years, who exhibited the clinical and radiologic features of a space-occupying mass strongly suggestive of neoplasia.
Irma E, Erana-Rojas +3 more
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Demyelinating disease presenting as a solitary contrast-enhancing mass poses a diagnostic challenge for both radiologists and surgical pathologists. We report the cases of two female patients, aged 23 and 37 years, who exhibited the clinical and radiologic features of a space-occupying mass strongly suggestive of neoplasia.
Irma E, Erana-Rojas +3 more
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Current Opinion in Neurology, 2003
To review recent advances in heritable demyelinating neuropathies and their genotype-phenotype correlations.Two themes dominated the literature on demyelinating neuropathies in the past 2 years: (1) the dissection of the localization and roles of new molecules in the axon-Schwann cell unit, including periaxin and connexin32, which are mutated in ...
Lan, Zhou, John W, Griffin
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To review recent advances in heritable demyelinating neuropathies and their genotype-phenotype correlations.Two themes dominated the literature on demyelinating neuropathies in the past 2 years: (1) the dissection of the localization and roles of new molecules in the axon-Schwann cell unit, including periaxin and connexin32, which are mutated in ...
Lan, Zhou, John W, Griffin
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Continuum, 2016
This review summarizes a general approach to pediatric demyelination as well as specific features of each of the acquired demyelinating syndromes to help clinicians in their evaluation of children with these disorders. Case studies are included to illustrate the expanding phenotype of many of these syndromes.With the creation of consensus definitions ...
Sona, Narula, Brenda, Banwell
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This review summarizes a general approach to pediatric demyelination as well as specific features of each of the acquired demyelinating syndromes to help clinicians in their evaluation of children with these disorders. Case studies are included to illustrate the expanding phenotype of many of these syndromes.With the creation of consensus definitions ...
Sona, Narula, Brenda, Banwell
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Nature Neuroscience, 2007
The loss of central nervous system myelin and the failure of remyelination by oligodendrocytes contribute to the functional impairment that characterizes diseases such as multiple sclerosis. Why myelin repair fails in multiple sclerosis is currently unclear; however, new understanding of the generation of oligodendrocytes and myelination during ...
Robert H, Miller, Sha, Mi
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The loss of central nervous system myelin and the failure of remyelination by oligodendrocytes contribute to the functional impairment that characterizes diseases such as multiple sclerosis. Why myelin repair fails in multiple sclerosis is currently unclear; however, new understanding of the generation of oligodendrocytes and myelination during ...
Robert H, Miller, Sha, Mi
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The ‘Attack of the Demyelinator’
Practical Neurology, 2013Here we present a novel way of accessing medical students and junior doctors and thus breaking down the much discussed and dreaded ‘neurophobia’ that is rampant in our medical schools and hospitals.1 In this comic strip entitled ‘The Attack of the Demyelinator’ we attempt to temper ‘neurophobia’ by enticing the student through graphic art.
Simon, Russell +4 more
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The Biochemistry of Demyelination and Demyelinating Diseases
1972Wallerian degeneration was the first experimental model of demyelination devised and has been widely investigated both structurally and biochemically. After severing a peripheral nerve there is increasing loss of cerebrosides, sphingomyelin, cholesterol and phospholipids, that of the cephalins starting earlier and exceeding that of lecithin [1]. During
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