Results 91 to 100 of about 70,385 (287)

Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired demyelinating neuropathy in which motor symptoms generally predominate over sensory symptoms and large fiber sensory dysfunction is more common than small fiber loss.
Benatar, Michael
core   +1 more source

Potassium Channel KIR4.1-Specific Antibodies and Acquired Demyelinating Disease

, 2014
Researchers at Technische Universitat, Munich, and other centers in Germany, studied the prevalence of KIR4.1-IgG by ELISA in 47 children with acquired demyelinating disease (ADD), in 22 with other neurologic diseases, 22 with autoimmune disease, and in ...
John J Millichap, J Gordon Millichap
core   +1 more source

Gephyrin Neurological Autoimmunity

Annals of Neurology, EarlyView.
Gephyrin is a postsynaptic scaffold protein essential for inhibitory neurotransmission. Gephyrin‐immunoglobulin G (IgG) was reported, decades ago, in a single case of paraneoplastic stiff‐person‐like syndrome, but its broader clinical relevance remains unknown.
Maria Chiara Pantuliano, Friederike A. Arlt, Naomi Arenson, Irena Dujmovic Basuroski, Divyanshu Dubey, Connie E. Lesnick, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael A. Lane, Andrew McKeon   +10 more
wiley   +1 more source

Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury

Cell Reports, 2015
Demyelinating diseases are characterized by a loss of oligodendrocytes leading to axonal degeneration and impaired brain function. Current strategies used for the treatment of demyelinating disease such as multiple sclerosis largely rely on modulation of
Simon M.G. Braun, Gregor-Alexander Pilz, Raquel A.C. Machado, Jonathan Moss, Burkhard Becher, Nicolas Toni, Sebastian Jessberger   +6 more
doaj   +1 more source

Treatment of a Large Cohort of Childhood Chronic Noninfectious Uveitis in a Multicentric Large Study: Adalimumab Versus Methotrexate as First‐Line Therapy

Arthritis &Rheumatology, EarlyView.
Objective Treatment of childhood chronic idiopathic uveitis (cCIU) is predominantly based on studies in juvenile idiopathic arthritis–associated uveitis and expert opinion. Our aim was to report the treatment outcomes of our cohort of cCIU. Methods Retrospective multicenter study involving the rheumatology and ophthalmology units at Florence, Italy ...
Ilaria Maccora, Catherine Guly, Cinzia de Libero, Giulia Carreras, Athimalaipet V. Ramanan, Gabriele Simonini   +5 more
wiley   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

IL-1 signal affects both protection and pathogenesis of virus-induced chronic CNS demyelinating disease

Journal of Neuroinflammation, 2012
Background Theiler’s virus infection induces chronic demyelinating disease in mice and has been investigated as an infectious model for multiple sclerosis (MS).
Kim Byung S, Jin Young-Hee, Meng Liping, Hou Wanqiu, Kang Hyun, Park Hey, Koh Chang-Sung   +6 more
doaj   +1 more source

Familial Hemophagocytic Lymphohistiocytosis Type 3 with Demyelinating CNS Disease

, 2009
A case of familial hemophagocytic lymphohistiocytosis type 3 (FHLH3) presenting in a 3-year-old boy with fulminant demyelinating neurological disease is reported by researchers at Kravis Children’s Hospital at Mount Sinai Medical Center, New ...
J Gordon Millichap
core   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

A Case Examination of a Rare and Devastating Demyelinating Disease

, 2023
Can you identify this rare demyelinating disease? Join Benjamin Osborne, MD, as he reviews a patient case designed to provide education on detection and diagnosis of a disorder that, if left untreated, has devastating consequences.
Benjamin Osborne, MD
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