Results 41 to 50 of about 4,914,110 (289)

Conduction in segmentally demyelinated mammalian central axons. [PDF]

, 1997
The prominent symptoms associated with central demyelinating diseases such as multiple sclerosis (MS) are primarily caused by conduction deficits in affected axons.
Paul A. Felts, Baker, Theresa A., Theresa A. Baker, Felts, PA, Smith, KJ, Smith, Kenneth J., Felts, Paul A.; id_orcid, Kenneth J. Smith, Baker, TA   +8 more
core   +1 more source

Relapsing forms of acute disseminated encephalomyelitis: current concepts of diagnosis and treatment, possible causes of chronic demyelinating process

Клинический разбор в общей медицине
Acute disseminated encephalomyelitis is an acute autoimmune inflammatory disease of the central nervous system, which is traditionally considered as a monophasic demyelinating process that develops mainly in children and adolescents. In recent years, the
Galina I. Sadekova, Madina A. Omarova, Alexey N. Boyko   +2 more
doaj   +1 more source

18F-Fluorodeoxy Glucose and 11C-Methionine Accumulation in Demyelinating Lesions

World Journal of Nuclear Medicine, 2022
Background Few studies have evaluated the accumulation of 18F-fluorodeoxyglucose (FDG), 11C-methionine (MET), and other positron emission tomography (PET) tracers in patients with demyelinating disease.
Noriaki Tomura, Toshiyuki Saginoya, Chikako Kaneko   +2 more
doaj   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Prostaglandin E2 produced following infection with Theiler's virus promotes the pathogenesis of demyelinating disease. [PDF]

PLoS ONE, 2017
Infection of various cells with Theiler's murine encephalomyelitis virus (TMEV) activates the TLR- and melanoma differentiation-associated gene 5 (MDA5)-dependent pathways, resulting in the production of IL-1β via the activation of caspase-1 upon ...
Seung Jae Kim, Young-Hee Jin, Byung S Kim   +2 more
doaj   +1 more source

The virology of demyelinating diseases [PDF]

Annals of Neurology, 1994
Infectious agents have been postulated as causes of multiple sclerosis for over a century. The possible role of a virus or viruses is supported by data that (1) a childhood exposure is involved and "viral" infections may precipitate exacerbations of disease, (2) experimental infections in animals and natural infections in humans can cause diseases with
openaire   +2 more sources

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Asymmetric Type F Botulism with Cranial Nerve Demyelination

Emerging Infectious Diseases, 2012
We report a case of type F botulism in a patient with bilateral but asymmetric neurologic deficits. Cranial nerve demyelination was found during autopsy. Bilateral, asymmetric clinical signs, although rare, do not rule out botulism.
Alina Filozov, Jessica A. Kattan, Lavanya Jitendranath, C. Gregory Smith, Carolina Lúquez, Quyen N. Phan, Ryan P. Fagan   +6 more
doaj   +1 more source

Destructive lesions in demyelinating disease

, 1991
Three cases are presented in which clinical and radiological features suggested the diagnosis of glioma but surgical biopsy revealed a demyelinating process, with tissue destruction and cyst formation in two.
Kermode, A.G., Youl, B.D., Stevens, J.M., Kendall, B.E., Moseley, I.F., Scaravilli, F., Kingsley, D., Earl, C.J., Thompson, A.J., Kirkham, F.J., Revesz, T., Barnard, R.O., McDonald, W.I.   +12 more
core   +1 more source