Results 111 to 120 of about 44,319 (309)

Forecasting Disease Burden In Philippines: A Symbolic Regression Analysis [PDF]

arXiv, 2021
Burden of disease measures the impact of living with illness and injury and dying prematurely and it is increasing worldwide leading cause of death both global and national. This paper aimed to propose an index of diseases and evaluate a mathematical model to describe the number of burden of disease by cause in the Philippines from 1990 - 2016. Through
arxiv  

Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18kDa Translocator Protein Radioligand [18F]DPA-714 [PDF]

, 2012
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Activated microglia/macrophages play a key role in the immunopathogenesis of MS and its corresponding animal models, experimental autoimmune encephalomyelitis (EAE).
Abourbeh, Galith, Boisgard, Raphael, Brulon, Vincent, Dollé, Frédéric, Dubois, Albertine, Fontyn, Yoann, Maroy, Renaud, Tavitian, Bertrand, Thézé, Benoit   +8 more
core   +1 more source

Endothelial PD‐1 Regulates Vascular Homeostasis and Oligodendrogenesis during Brain Development

Advanced Science, EarlyView.
Vascular endothelial cells are fundamental for angiogenesis and brain development. This study reveals that endothelial programmed cell death 1 (PD‐1) is critical for cerebral angiogenesis and blood brain barrier (BBB) maturation. It also mediates interaction with oligodendrocyte precursor cells (OPCs), modulating OPCs differentiation and myelination ...
Tingting He, Mengtian Zhang, Jie Qin, Yanyan Wang, Sihan Li, Chaoyi Du, Jianwei Jiao, Fen Ji   +7 more
wiley   +1 more source

P2T2: a Physically-primed deep-neural-network approach for robust $T_{2}$ distribution estimation from quantitative $T_{2}$-weighted MRI [PDF]

arXiv, 2022
Estimating $T_2$ relaxation time distributions from multi-echo $T_2$-weighted MRI ($T_2W$) data can provide valuable biomarkers for assessing inflammation, demyelination, edema, and cartilage composition in various pathologies, including neurodegenerative disorders, osteoarthritis, and tumors.
arxiv  

Subventricular Zone Microstructure in Pediatric‐Onset Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective The aim of this study was to explore the microstructural dynamics of the subventricular zone (SVZ) with aging and their associations with clinical disability and brain structural damage in pediatric‐onset multiple sclerosis (MS) patients. Methods One‐hundred and forty‐one pediatric‐onset MS patients (67 pediatric and 74 adults with pediatric ...
Monica Margoni, Loredana Storelli, Elisabetta Pagani, Paolo Preziosa, Damiano Mistri, Mor Gueye, Martina Rubin, Lucia Moiola, Massimo Filippi, Maria Assunta Rocca   +9 more
wiley   +1 more source

Diffusion Kurtosis Imaging maps neural damage in the EAE model of multiple sclerosis [PDF]

arXiv, 2018
Diffusion kurtosis imaging (DKI), is an imaging modality that yields novel disease biomarkers and in combination with nervous tissue modeling, provides access to microstructural parameters. Recently, DKI and subsequent estimation of microstructural model parameters has been used for assessment of tissue changes in neurodegenerative diseases and their ...
arxiv  

The effect of realistic geometries on the susceptibility-weighted MR signal in white matter [PDF]

, 2017
Purpose: To investigate the effect of realistic microstructural geometry on the susceptibility-weighted magnetic resonance (MR) signal in white matter (WM), with application to demyelination. Methods: Previous work has modeled susceptibility-weighted signals under the assumption that axons are cylindrical. In this work, we explore the implications of
arxiv   +1 more source

Increased age and male sex are independently associated with higher frequency of blood–cerebrospinal fluid barrier dysfunction using the albumin quotient [PDF]

, 2020
Background: The cerebrospinal fluid (CSF)/serum quotient of albumin (QAlb) is the most used biomarker for the evaluation of blood–cerebrospinal fluid barrier (B-CSF-B) permeability.
Alessi, Francesca, Baldi, Eleonora, Bellini, Tiziana, Caniatti, Luisa M., Casetta, Ilaria, Castellazzi, Massimiliano, Fainardi, Enrico, Granieri, Enrico, Morotti, Andrea, Pilotto, Silvy, Pugliatti, Maura, Tamborino, Carmine, Trentini, Alessandro   +12 more
core   +1 more source

Accelerated Cellular Senescence in Progressive Multiple Sclerosis: A Histopathological Study

Annals of Neurology, EarlyView.
Objective The neurodegenerative processes driving the build‐up of disability in progressive multiple sclerosis (P‐MS) have not been fully elucidated. Recent data link cellular senescence (CS) to neurodegeneration. We investigated for evidence of CS in P‐MS and sought to determine its pattern.
Dimitrios Papadopoulos, Roberta Magliozzi, Sara Bandiera, Ilaria Cimignolo, Elena Barusolo, Lesley Probert, Vassilis Gorgoulis, Richard Reynolds, Richard Nicholas   +8 more
wiley   +1 more source

Bibliometric analysis of the intestinal microbiota and demyelinating diseases, particularly multiple sclerosis, since 2014

Frontiers in Neuroscience
BackgroundThe gut–brain axis (GBA) represents a complex, bidirectional communication network that connects the central nervous system (CNS) and the gastrointestinal system.
Ling Chen, Le-Le Wu, Chang-Yin Yu, Zu-Cai Xu, Hao Huang   +4 more
doaj   +1 more source