Results 131 to 140 of about 44,319 (309)
European Journal of Clinical Investigation, Volume 53, Issue 1, January 2023., 2023 Graphical abstract MP3‐pulses‐COVID‐19 trial. Abstract Background The efficacy and safety of high versus medium doses of glucocorticoids for the treatment of patients with COVID‐19 has shown mixed outcomes in controlled trials and observational studies.
Luis Corral‐Gudino +21 more
wiley +1 more source
Multiple sclerosis lesion enhancement and white matter region estimation using hyperintensities in FLAIR images [PDF]
arXiv, 2018 Multiple sclerosis (MS) is a demyelinating disease that affects more than 2 million people worldwide. The most used imaging technique to help in its diagnosis and follow-up is magnetic resonance imaging (MRI). Fluid Attenuated Inversion Recovery (FLAIR) images are usually acquired in the context of MS because lesions often appear hyperintense in this ...
arxiv
The microglial "activation" continuum: from innate to adaptive responses [PDF]
, 2005 Microglia are innate immune cells of myeloid origin that take up residence in the central nervous system (CNS) during embryogenesis. While classically regarded as macrophage-like cells, it is becoming increasingly clear that reactive microglia play more ...
Nikolic, Veljko +2 more
core +3 more sources
European Journal of Neuroscience, Volume 56, Issue 12, Page 6099-6114, December 2022., 2022 Using environmental enrichment to physiologically induce neuroplasticity in the young adult mouse, we find dynamic structural remodelling of axons and their pre‐existing myelin sheaths. Additionally, we find that oligodendrocytes respond primarily with an increase in differentiation and regionally specific decreases in progenitor density. These results
Madeline Nicholson +6 more
wiley +1 more source
Multiple Sclerosis Lesion Inpainting Using Non-Local Partial Convolutions [PDF]
arXiv, 2018 Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that results in focal injury to the grey and white matter. The presence of white matter lesions biases morphometric analyses such as registration, individual longitudinal measurements and tissue segmentation for brain volume measurements.
arxiv
Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. [PDF]
, 2019 Mesenchymal stem/stromal cells (MSCs) display potent immunomodulatory and regenerative capabilities through the secretion of bioactive factors, such as proteins, cytokines, chemokines as well as the release of extracellular vesicles (EVs).
Barthe, Sylvain +11 more
core +2 more sources
European Journal of Neurology, Volume 30, Issue 2, Page 501-510, February 2023., 2023 In this study, Doneddu et al. developed a score that permitted an accurate discrimination, amongst patients with anti‐myelin‐associated‐glycoprotein (anti‐MAG) antibodies, of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and patients with anti‐MAG neuropathy.
Pietro E. Doneddu +12 more
wiley +1 more source
The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. [PDF]
, 2007 Perivascular microglia activation is a hallmark of inflammatory demyelination in multiple sclerosis (MS), but the mechanisms underlying microglia activation and specific strategies to attenuate their activation remain elusive.
Adams, Ryan A +7 more
core
Primary Sjögren syndrome‐related peripheral neuropathy: A systematic review and meta‐analysis
European Journal of Neurology, Volume 30, Issue 1, Page 255-265, January 2023., 2023 The pooled prevalence of peripheral neuropathy in primary Sjögren syndrome (pSS) is estimated to be 15% (95% confidence interval = 11%–21%). pSS‐related neuropathy usually manifests in the 6th decade of life. The commonest type is distal axonal polyneuropathy, followed by sensory ganglionopathy. Abstract Background and purpose Primary Sjögren syndrome (
Andreas Liampas +10 more
wiley +1 more source
Expression and Differential Responsiveness of Central Nervous System Glial Cell Populations to the Acute Phase Protein Serum Amyloid A [PDF]
, 2017 Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves hepatic production of acute-phase proteins, including serum amyloid A (SAA). Extrahepatically, SAA immunoreactivity is found in axonal myelin sheaths of cortex
A Castellheim +77 more
core +2 more sources