Results 151 to 160 of about 33,616 (245)

Analyzing multiclonality of Staphylococcus aureus in clinical diagnostics using spa-based denaturing gradient gel electrophoresis. [PDF]

open access: yesJ Clin Microbiol, 2011
Matussek A   +6 more
europepmc   +1 more source

Engineering Cadherin‐Guided MSC Aggregates to Empower Synergistic Neurovascular Repair After Stroke

open access: yesAggregate, Volume 7, Issue 3, March 2026.
A cadherin‐directed bioengineering strategy transforms mesenchymal stem cell aggregation from passive clustering into active functional programming. The resulting cadherin‐guided aggregates exhibit reinforced microstructure, stress resistance, and an enhanced pro‐regenerative secretome, enabling coordinated neurovascular repair in ischemic stroke.
Guoqiang Chen   +8 more
wiley   +1 more source

Analysis of Reactive Oxygen Species–Induced Cellular Damage in Cervical Cancer

open access: yesCurrent Protocols, Volume 6, Issue 3, March 2026.
Abstract Reactive oxygen species (ROS) are highly reactive oxygen‐based molecules comprising hydrogen peroxide, hydroxyl radicals, superoxide anion, and singlet oxygen. These species are produced intracellularly and play an important role in cellular signaling and metabolism. Their high reactivity damages intracellular macromolecules such as lipids and
Hoi Ching Cherry Chan   +4 more
wiley   +1 more source

CMA‐mediated USP9X degradation promotes SHH medulloblastoma progression by facilitating SUFU ubiquitination

open access: yesClinical and Translational Medicine, Volume 16, Issue 3, March 2026.
Deubiquitinase USP9X suppresses SHH Medulloblastoma progression by facilitating SUFU ubiquitination. SHH promotes USP9X degradation through the CMA pathway. Combined inhibition of CMA and SHH pathway had a synergically therapeutic effect on SHH Medulloblastoma.
Binbin Gao   +12 more
wiley   +1 more source

Marine n‐3 Polyunsaturated Fatty Acids Mitigate Obesity Traits Through PRDM16‐Driven Gene–Nutrient Interaction and Spatiotemporal Scale Browning Process

open access: yesFood Frontiers, Volume 7, Issue 2, March 2026.
This large cohort study of 45,664 participants from the UK Biobank provides strong epidemiological evidence that fish oil use was associated with 12% and 7% lower risks of obesity and high body fat percentage, respectively. Mechanistically, marine n‐3 polyunsaturated fatty acids mitigate obesity traits through PRDM16‐driven gene–nutrient interactions ...
Xiaohui Liu   +12 more
wiley   +1 more source

Development of a Live‐Cell Imaging Assay to Elucidate Spatiotemporal Dynamics of Extracellular Vesicle Fusion with Target Cells

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
We present a novel live‐cell imaging assay for detection of extracellular vesicle (EV)‐binding, ‐uptake, and ‐fusion in time and space. Using EVs carrying the fusogen VSV‐G, we demonstrate real‐time imaging of EV‐fusion, quantification of fusion kinetics and efficiency, and subcellular localization of fusion events.
Jasper van den Ende   +5 more
wiley   +1 more source

Engineered CAR‐T–Derived Exosomes Co‐Delivering miR‐145 and Cytotoxic Proteins for Targeted Solid Tumour Therapy

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Chimeric antigen receptor T cell (CAR‐T) therapy has demonstrated remarkable efficacy in haematologic malignancies but remains constrained in solid tumours due to limited tumour penetration, immunosuppressive microenvironments and the risk of cytokine release syndrome (CRS).
Ruyue Yang   +10 more
wiley   +1 more source

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