Results 111 to 120 of about 23,240 (264)

Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin

Allergy, EarlyView.
This study included 28 amoxicillin‐allergic patients and 11 healthy exposed controls. Mast cells were differentiated from CD34+ progenitors over 8 weeks using cytokine cocktails. The mast cell activation test involved sensitization with patient or control sera and stimulation with free amoxicillin or G4/G5‐AXO dendrimers with successfully activated ...
Jose A. Céspedes, Clara Lebrón‐Martín, Lucía Vallecillos‐Azor, Pablo Torres, Amene Tesfaye Ayane, Gádor Bogas, María Salas, Adriana Ariza, María Isabel Montañez, María José Torres, Carlos José Aranda, Cristobalina Mayorga   +11 more
wiley   +1 more source

Glycopeptide dendrimer colchicine conjugates targeting cancer cells

, 2010
International audienceScreening of a 65,536-member one-bead-one-compound (OBOC) combinatorial library of glycopeptide dendrimers of structure ((betaGal)(n)(+1)X(8)X(7)X(6)X(5))(2)DapX(4)X(3)X(2)X(1)(beta-Gal)(m) (betaGal=beta-galactosyl-thiopropionic ...
Reymond, Jean-Louis, Dubois, Joëlle, Johansson, Emma M V, Johansson, Emma M.V., Darbre, Tamis   +4 more
core   +1 more source

Chemistry of Secondary Metabolites (Production, Properties, Biological Activity, etc.): Solubility Study of the Interaction between Pamam G-3 Dendrimer and 5 Fluorouracil in Aqueous Solution

International Journal of Secondary Metabolite, 2016
Poly(amidoamine) dendrimers (PAMAM) are polymeric macromolecules that can find their use as carriers of small ligand molecules such as cosmetics and drugs.
B. PALECZ, A. BUCZKOWSKI, L. B. ZAVODNIK   +2 more
doaj  

Mystery and misery of locally‐delivered drug therapy in periodontics. Historical concepts and current state

Periodontology 2000, EarlyView.
Abstract The primary objective is to critically analyze approaches to local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential of local treatments in contrast to their actual clinical effectiveness.
Andrea Mombelli, Alkisti Zekeridou
wiley   +1 more source

Chemical‐Assembled Macrophage‐Engaging Glypican‐3 × Signal Regulatory Protein‐α (SIRP‐α) Bispecific Antibody for Immunotherapy Against Liver Cancer

MedComm, Volume 7, Issue 7, July 2026.
We developed a novel chemical strategy to generate a glypican‐3 × SIRP‐α bispecific antibody that simultaneously blocks the CD47 “don't eat me” signal, engages macrophages to target liver cancer cells for enhanced phagocytosis, and antigen presentation. This novel combination of targets demonstrates remarkable efficacy in vitro and in vivo.
Bo Tang, Wing Hei Leung, Chihao Shao, Dongfang Li, Kwai Man Lau, Macro K. H. Lui, Jingyi Liu, Jacky C. H. Chu, Clare S. W. Yan, Chi‐Ming Che, Xuechen Li, Wing‐Tak Wong, Larry Ming Cheung Chow, Terence K. W. Lee, Clarence T. T. Wong   +14 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Tuning catalytic activity and sensitivity in urease‐based thin film biosensors using conjugated polymers and eugenol/biseugenol

Polymer International, Volume 75, Issue 7, Page 609-617, July 2026.
Hybrid thin films of conjugated polymers and urease modified with eugenol derivatives show that polymer–biomolecule interactions enhance catalytic activity while distinctly modulating electrolyte–insulator–semiconductor sensor sensitivity. Abstract Thin films have emerged as promising platforms for biosensor development due to their versatility and ...
Thaísa da Silva de Souza, Cléber Gomes de Jesus, Paulo Vitor de Morais, José Roberto Siqueira Junior, Michael Josef Schöning, João Henrique Ghilardi Lago, Luciano Caseli, Laura Oliveira Péres   +7 more
wiley   +1 more source

Progress Toward Biodegradable Triazine Dendrimers Using Triazinyl Hydrazone Linkages

, 2015
This research aims to synthesize a triazine dendrimer with labile arms through the incorporation of hydrazone linkages. This dendrimer should be susceptible to hydrolysis in acidic conditions, be soluble in water, relatively non-toxic, and be degradable ...
Zeiser, Michael
core  

The Antibacterial Effect of Polypropylenimine-G2 Dendrimer on Escherichia coli, Enterobacter cloacae , Bacillus subtilis, and Staphylococcus aureus

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2014
Backgrounds and Objectives:Dendrimers are a new class of synthetic macromolecules, which have many applications in medical sciences.This study was carried out with the purpose ofinvestigating the antibacterial effect of polypropylenimine-G2 (PPI-G2 ...
Hassan Izanlo, Mohammad Ahmadi Jebelli, Gharib Mjidi, Mohammad Khazaei, Hamid Reza Tashayoe, Vahid Vazirirad, Hossein Aghababaei, Behnam Vakili   +7 more
doaj  

Autocatalytic Deprotection of Diboronate‐Protected Quinones via Redox Cross‐Catalysis: Mechanistic Insights Into Double Masking Strategies

ChemSystemsChem, Volume 8, Issue 4, July 2026.
Mechanistic insights and design principles of diprotected molecular probes for autocatalytic redox amplification systems: assessing the influence of molecular structure symmetry and electronic substituent effects on the double deprotection and autocatalytic response. ABSTRACT We report an autocatalytic molecular amplification system based on the double
Pan Hui, Alexandra Pastor, Mathieu Branca, Benoît Limoges, François Mavré   +4 more
wiley   +1 more source