Results 81 to 90 of about 274,434 (381)

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Calcium Dynamics in Basal Dendrites of Layer 5A and 5B Pyramidal Neurons Is Tuned to the Cell-Type Specific Physiological Action Potential Discharge

open access: yesFrontiers in Cellular Neuroscience, 2017
Layer 5 (L5) is a major neocortical output layer containing L5A slender-tufted (L5A-st) and L5B thick-tufted (L5B-tt) pyramidal neurons. These neuron types differ in their in vivo firing patterns, connectivity and dendritic morphology amongst other ...
Patrik Krieger   +6 more
doaj   +1 more source

Analyzing Branch‐specific Dendritic Spikes Using an Ultrafast Laser Scalpel

open access: yesFrontiers in Physics, 2020
Dendritic spikes facilitate neuronal computation and they have been reported to occur in various regions of the dendritic tree of cortical neurons.
Michael L. Castañares   +3 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

NANOSTRUCTURAL PROCESSES OF MELTING, CRYSTALLIZATION AND MODIFYINGS OF METALS

open access: yesЛитьë и металлургия, 2015
It is shown that melting, crystallization and modifying of metals are difficult nanostructural processes. The nanocrystals and atoms of metals, the centers of crystallization of dendrites, surface-active elements, gases modifying elements, poorly soluble
V. Yu. Stetsenko
doaj  

Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons

open access: yesCell Reports, 2017
Dendrite aberration is a common feature of neurodegenerative diseases caused by protein toxicity, but the underlying mechanisms remain largely elusive.
Chang Geon Chung   +18 more
doaj   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

open access: yesMolecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza   +5 more
wiley   +1 more source

THERMODYNAMICS AND NANOSTRUCTURAL MECHANISMS OF PROCESSES OF MELTING AND CRYSTALLIZATION OF METALS

open access: yesЛитьë и металлургия, 2016
Melting and crystallization of metals are equilibrium thermodynamic processes. As the main structural units of dendrites serve construction nanocrystals which are formed of elementary nanocrystals.
V. Yu. Stetsenko
doaj  

Current-induced dendritic magnetic instability in superconducting MgB2 films

open access: yes, 2002
Magneto-optical imaging reveals that in superconducting films of MgB2 a transport current creates avalanche-like flux dynamics where highly branching dendritic penetration patterns are formed.
Bobyl, A. V.   +6 more
core   +1 more source

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