Results 81 to 90 of about 284,053 (380)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Current-induced dendritic magnetic instability in superconducting MgB2 films

, 2002
Magneto-optical imaging reveals that in superconducting films of MgB2 a transport current creates avalanche-like flux dynamics where highly branching dendritic penetration patterns are formed.
Bobyl, A. V., Choi, E. M., Johansen, T. H., Kang, W. N., Kim, H. J., Lee, S. I., Shantsev, D. V.   +6 more
core   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Genes, Cells and Brain Areas of Intelligence

Frontiers in Human Neuroscience, 2019
What is the neurobiological basis of human intelligence? The brains of some people seem to be more efficient than those of others. Understanding the biological foundations of these differences is of great interest to basic and applied neuroscience ...
Natalia A. Goriounova, Huibert D. Mansvelder   +1 more
doaj   +1 more source

Solidification of Al alloys under electromagnetic pulses and characterization of the 3D microstructures under synchrotron x-ray tomography [PDF]

, 2015
A novel programmable electromagnetic pulse device was developed and used to study the solidification of Al-15 pct Cu and Al-35 pct Cu alloys. The pulsed magnetic fluxes and Lorentz forces generated inside the solidifying melts were simulated using finite
Andrew J. Bodey, C. Song, C.Y. Ho, Christoph Rau, D. Bernard, E. Basham, E.G. Bakhoum, E.O. Hall, G.I. Eskin, G.N. Ramachandran, G.P. Jones, J.A. Dantzig, J.A. Wert, Jiawei Mi, L. Li, M. Garnier, M. Guo, M. Johnsson, M.C. Flemings, M.J. Li, N. Pei, N.Y. Konstantinova, P. Koltun, Peter Lobo Kazinczi, Q. Li, S. Asai, S. Bartkevičius, S. Dan, S. Eckert, S. Tamirisakandala, S. Titarenko, S.D. Pawar, S.H. Hanhn, T. Campanella, Theerapatt Manuwong, W. Dai, Wei Zhang, X. Li, Y. Du, Y. Plevachuk, Y.J. Zhang, Z. Shu-cai, Z.X. Yin   +42 more
core   +1 more source

Dendrite-free lithium metal anodes enabled by an ordered conductive Ni-based catecholate interlayer for solid-state lithium batteries [PDF]

, 2023
Tianyuan Wang, Yuezhen Mao, Jianbing Wang, Chunwen Sun   +3 more
openalex   +1 more source

Of microtubules and memory: implications for microtubule dynamics in dendrites and spines

Molecular Biology of the Cell, 2017
Microtubules (MTs) are cytoskeletal polymers composed of repeating subunits of tubulin that are ubiquitously expressed in eukaryotic cells. They undergo a stochastic process of polymerization and depolymerization from their plus ends termed dynamic ...
E. Dent
semanticscholar   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders

Proteomes, 2018
The mammalian nervous system is an immensely heterogeneous organ composed of a diverse collection of neuronal types that interconnect in complex patterns.
Yi-Zhi Wang, Jeffrey N. Savas
doaj   +1 more source

Travelling waves in a model of quasi-active dendrites with active spines [PDF]

, 2010
Dendrites, the major components of neurons, have many different types of branching structures and are involved in receiving and integrating thousands of synaptic inputs from other neurons.
Abbott, Alvarez, Baer, Bhatt, Bloodgood, Bressloff, Brown, Cajal, Cook, Coombes, Coombes, Coombes, Coombes, Coombes, Cox, Hodgkin, James, Johnston, Katz, Koch, Larkum, Lord, Magee, Mauro, Mel, Miller, Miller, Narayanan, Scott, Segal, Segev, Shepherd, Spruston, Svoboda, Timofeeva, Timofeeva, Timofeeva, Tsay, Ulrich, Williams, Y. Timofeeva   +40 more
core   +1 more source