Results 121 to 130 of about 825,352 (312)

A fast-progressing orthotopic ovarian cancer model reveals synergistic antitumor effects of AXL-targeting nanobodies and Olaparib

Gynecologic Oncology Reports
Objective: Ovarian cancer (OC) is the deadliest gynecological malignancy, with patients experiencing late diagnosis and high recurrence. AXL is highly expressed in OC and correlates with worse prognosis.
Aarushi A. Caro, Alícia Gordún Peiró, Eva Hadadi, Yani Berckmans, Yvon Elkrim, Ayla Debraekeleer, Gisèle Mateu Cabrera, Kim De Veirman, An Coosemans, Damya Laoui   +9 more
doaj   +1 more source

Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.

, 2008
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (Mtb) infection remains controversial. To address the impact of TLR-mediated pathogen recognition and MyD88-dependent signaling events on anti ...
Abel, Bafica, Blander, Branger, Brightbill, Carroll, Cooper, Drennan, Feng, Flynn, Flynn, Fremond, Fremond, Gilleron, Gutierrez, Han, Holscher, Holscher, Hsieh, Jones, Kamath, Kaufmann, Kaufmann, Kawai, Krieg, MacMicking, MacMicking, Maher, Martinon, Means, Means, Means, Medzhitov, North, Quesniaux, Rausch, Reiling, Ryffel, Scanga, Scanga, Schaible, Seki, Shi, Shi, Shim, Sugawara, Sugawara, Sun, Takeuchi, Thoma-Uszynski, Trinchieri, Underhill, van der Wel, Yates   +53 more
core   +1 more source

Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME

Advanced Functional Materials, EarlyView.
A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li, E Pang, Snehasish Debnath, Jia Hong, Aojun Qiu, Dongeun Kim, Goeun Kim, Minhuan Lan, Min‐Goo Lee, Qian‐Yong Cao, Jong Seung Kim   +10 more
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Enhanced induction of HIV-specific CTL by dendritic cell-targeted delivery of SOCS-1 siRNA [PDF]

, 2010
Sandesh Subramanya, Chunting Ye, Sang Soo Kim, Premalata Shankar   +3 more
openalex   +1 more source

Engineered Interface and Spatial Arrangement of Inorganic Components for Dendrite‐Free Li Anodes in Carbonate‐Based Electrolyte

Advanced Functional Materials, EarlyView.
A solid‐state ion exchange strategy constructs dentrimental Li2CO3 into a high‐modulus, high‐surface‐energy interface to enable dendrite‐free deposition of Li metal anode in the harsh carbonate‐based electrolyte. Abstract The practical application of lithium metal batteries (LMBs) in carbonate‐based electrolytes is hindered by uncontrolled lithium (Li)
Qiannan Zhao, Kaiqi Zhao, Jae‐Hoon Baek, Ronghua Wang, Chaohe Xu, Jong‐Beom Baek   +5 more
wiley   +1 more source

Ryanodine receptor 1 signaling in dendritic cells [PDF]

, 2009
Mirko Vukcevic, Giulio C. Spagnoli, Giandomenica Iezzi, Francesco Zorzato, Susan Treves   +4 more
openalex   +1 more source

Using In Situ TEM to Understand the Surfaces of Electrocatalysts at Reaction Conditions: Single‐Atoms to Nanoparticles

Advanced Functional Materials, EarlyView.
This review summarizes recent advances in closed‐cell in situ TEM strategies for accurate determination of the activity and stability of single‐atom catalyst systems during operation. Operando conditions causing dynamic changes of SAC systems are highlighted and we explain why ensemble average‐based optical techniques may benefit from the technological
Martin Ek, Soshan Cheong, Julie Cairney, Richard D. Tilley, Ingemar Persson   +4 more
wiley   +1 more source

Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium. [PDF]

, 2019
Dendritic spines are small subcompartments that protrude from the dendrites of neurons and are important for signaling activity and synaptic communication. These subcompartments have been characterized to have different shapes.
Bartol, Tom, Bell, Miriam, Rangamani, Padmini, Sejnowski, Terrence   +3 more
core  

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source