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Actin in Dendritic Spines: Connecting Dynamics to Function [PDF]
Journal of Cell Biology, 2010 Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the postsynaptic part of most excitatory synapses and are major sites of information processing and storage in the brain.
Casper Hoogenraad, Pirta Hotulainen
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Microtubule Dynamics in Dendritic Spines
2010Neuronal microtubules recently emerged as temporal and spatial regulators of dendritic spines, the major sites of excitatory synaptic input. By imaging microtubules in cultured mature primary hippocampal neurons using fluorescently tagged tubulin and microtubule plus-end binding (EB) protein EB3, dynamic microtubules were found to regularly depart from
Kapitein, Lukas +2 more
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Dendrite and dendritic spine alterations in alzheimer models
Journal of Neurocytology, 2004Synaptic damage and loss are factors that affect the degree of dementia experienced in Alzheimer disease (AD) patients. Multicolor DiOlistic labeling of the hippocampus has been undertaken which allows the full dendritic arbor of targeted neurons to be imaged.
Donna L, Moolman +3 more
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The Spine Apparatus, Synaptopodin, and Dendritic Spine Plasticity
The Neuroscientist, 2010The spine apparatus (SA) is an essential component of mature dendritic spines of cortical and hippocampal neurons, yet its functions are still enigmatic. Synaptopodin (SP), an actin-binding protein, colocalizes with the SA. Hippocampal neurons in SP-knockout mice lack SA, and they express lower LTP.
Menahem, Segal +2 more
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On the electrical function of dendritic spines
Trends in Neurosciences, 2004Dendritic spines mediate most excitatory inputs in the brain, yet their function is still unclear. Imaging experiments have demonstrated their role in biochemical compartmentalization at individual synapses, yet theoretical studies have suggested that they could serve an electrical function in transforming synaptic inputs and transmitting dendritic ...
David, Tsay, Rafael, Yuste
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Dendritic spine morphogenesis and plasticity
Journal of Neurobiology, 2005AbstractDendritic spines are small protrusions off the dendrite that receive excitatory synaptic input. Spines vary in size, likely correlating with the strength of the synapses they form. In the developing brain, spines show highly dynamic behavior thought to facilitate the formation of new synaptic contacts.
Lippman-Bell, Jocelyn, Dunaevsky, A.
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Dendritic spine formation and stabilization
Current Opinion in Neurobiology, 2009Formation, elimination and remodeling of excitatory synapses on dendritic spines represent a continuous process that shapes the organization of synaptic networks during development. The molecular mechanisms controlling dendritic spine formation and stabilization therefore critically determine the rules of network selectivity.
Yoshihara, Yoshihiro +2 more
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1998
Dendritic spines, sometimes also called dendritic thorns, are tiny, specialized protoplasmic protuberances that cover the surface of many neurons. First described by Ramón y Cajal (1909; 1991) in light-microscopic studies of Golgi stained tissue, they are among the most striking subneuronal features of many neurons.
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Dendritic spines, sometimes also called dendritic thorns, are tiny, specialized protoplasmic protuberances that cover the surface of many neurons. First described by Ramón y Cajal (1909; 1991) in light-microscopic studies of Golgi stained tissue, they are among the most striking subneuronal features of many neurons.
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2010
A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity. Most neurons in the brain are covered by dendritic spines, small protrusions that arise from dendrites, covering them like leaves on
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A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity. Most neurons in the brain are covered by dendritic spines, small protrusions that arise from dendrites, covering them like leaves on
openaire +1 more source
Molecular morphogens for dendritic spines
Trends in Neurosciences, 2002Three protein components of the postsynaptic density--Shank, Homer and SPAR--have been found to regulate the structural and molecular organization of dendritic spines. These new studies reveal linkages between receptor complexes, the actin cytoskeleton and signaling molecules that help shape spines.
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