Results 1 to 10 of about 58,744 (263)
Effects of cholestasis and hyperammonemia on dendritic spine density and turnover in rat hippocampal neurons [PDF]
Scientific ReportsAdults and children with cholestatic liver disease are at risk for type C hepatic encephalopathy (HE) and may present lifelong neurocognitive impairment.
Laurianne Giovannoni +6 more
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PLoS Computational Biology, 2022 Dendritic spines are highly dynamic neuronal compartments that control the synaptic transmission between neurons. Spines form ultrastructural units, coupling synaptic contact sites to the dendritic shaft and often harbor a spine apparatus organelle ...
James Rosado +5 more
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Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling. [PDF]
PLoS ONE, 2015 During development, scaffold proteins serve as important platforms for orchestrating signaling complexes to transduce extracellular stimuli into intracellular responses that regulate dendritic spine morphology and function.
Yu Chen +8 more
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Cells, 2021 Dendritic spines are small, bulbous protrusions along neuronal dendrites where most of the excitatory synapses are located. Dendritic spine density in normal human brain increases rapidly before and after birth achieving the highest density around 2–8 ...
Pushpa Khanal, Pirta Hotulainen
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Effects of Tropomodulin 2 on Dendritic Spine Reorganization and Dynamics
Biomolecules, 2023 Dendritic spines are actin-rich protrusions that receive a signal from the axon at the synapse. Remodeling of cytoskeletal actin is tightly connected to dendritic spine morphology-mediated synaptic plasticity of the neuron.
Balaganesh Kuruba +6 more
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Cells, 2021 Dendritic spines are small, thin, hair-like protrusions found on the dendritic processes of neurons. They serve as independent compartments providing large amplitudes of Ca2+ signals to achieve synaptic plasticity, provide sites for newer synapses ...
Arehally M. Mahalakshmi +8 more
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Scientific Reports, 2021 A major complication with spinal cord injury (SCI) is the development of spasticity, a clinical symptom of hyperexcitability within the spinal H-reflex pathway.
Curtis A. Benson +7 more
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eLife, 2022 Dendritic spines are the central postsynaptic machinery that determines synaptic function. The F-actin within dendritic spines regulates their dynamic formation and elimination.
Soo Jeong Kim +9 more
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Frontiers in Cellular Neuroscience, 2017 Psychostimulant drugs of abuse increase dendritic spine density in reward centers of the brain. However, little is known about their effects in the hippocampus, where activity-dependent changes in the density of dendritic spine are associated with ...
Soledad Ferreras +13 more
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Combined role of seizure-induced dendritic morphology alterations and spine loss in newborn granule cells with mossy fiber sprouting on the hyperexcitability of a computer model of the dentate gyrus. [PDF]
PLoS Computational Biology, 2014 Temporal lobe epilepsy strongly affects hippocampal dentate gyrus granule cells morphology. These cells exhibit seizure-induced anatomical alterations including mossy fiber sprouting, changes in the apical and basal dendritic tree and suffer substantial ...
Julian Tejada +2 more
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