Results 1 to 10 of about 95,132 (154)

Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation [PDF]

Molecular and Cellular Neurosciences, 2013
Dendritic spines are major sites of excitatory synaptic transmission and changes in their numbers and morphology have been associated with neurodevelopmental and neurodegenerative disorders.
Brian G Hiester, Patricia C Salinas, Kevin R Jones   +2 more
exaly   +3 more sources

Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations

Neurobiology of Disease, 2009
Rett syndrome (RTT) is an X chromosome-linked neurodevelopmental disorder associated with the characteristic neuropathology of dendritic spines common in diseases presenting with mental retardation (MR).
Christopher A Chapleau, Shinichi Kudo, Dawna L Armstrong   +2 more
exaly   +3 more sources

Effects of cholestasis and hyperammonemia on dendritic spine density and turnover in rat hippocampal neurons [PDF]

Scientific Reports
Adults and children with cholestatic liver disease are at risk for type C hepatic encephalopathy (HE) and may present lifelong neurocognitive impairment.
Laurianne Giovannoni, Katarzyna Pierzchala, Mathias De Roo, Olivier Braissant, Stephen Bruce, Valérie Anne McLin, Laszlo Vutskits   +6 more
doaj   +2 more sources

Calcium modeling of spine apparatus-containing human dendritic spines demonstrates an "all-or-nothing" communication switch between the spine head and dendrite.

PLoS Computational Biology, 2022
Dendritic spines are highly dynamic neuronal compartments that control the synaptic transmission between neurons. Spines form ultrastructural units, coupling synaptic contact sites to the dendritic shaft and often harbor a spine apparatus organelle ...
James Rosado, Viet Duc Bui, Carola A Haas, Jürgen Beck, Gillian Queisser, Andreas Vlachos   +5 more
doaj   +1 more source

Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling. [PDF]

PLoS ONE, 2015
During development, scaffold proteins serve as important platforms for orchestrating signaling complexes to transduce extracellular stimuli into intracellular responses that regulate dendritic spine morphology and function.
Yu Chen, Zhuoyi Liang, Erkang Fei, Yuewen Chen, Xiaopu Zhou, Weiqun Fang, Wing-Yu Fu, Amy K Y Fu, Nancy Y Ip   +8 more
doaj   +1 more source

Dendritic Spine Initiation in Brain Development, Learning and Diseases and Impact of BAR-Domain Proteins

Cells, 2021
Dendritic spines are small, bulbous protrusions along neuronal dendrites where most of the excitatory synapses are located. Dendritic spine density in normal human brain increases rapidly before and after birth achieving the highest density around 2–8 ...
Pushpa Khanal, Pirta Hotulainen
doaj   +1 more source

Effects of Tropomodulin 2 on Dendritic Spine Reorganization and Dynamics

Biomolecules, 2023
Dendritic spines are actin-rich protrusions that receive a signal from the axon at the synapse. Remodeling of cytoskeletal actin is tightly connected to dendritic spine morphology-mediated synaptic plasticity of the neuron.
Balaganesh Kuruba, Nickolas Starks, Mary Rose Josten, Ori Naveh, Gary Wayman, Marina Mikhaylova, Alla S. Kostyukova   +6 more
doaj   +1 more source

Impact of Pharmacological and Non-Pharmacological Modulators on Dendritic Spines Structure and Functions in Brain

Cells, 2021
Dendritic spines are small, thin, hair-like protrusions found on the dendritic processes of neurons. They serve as independent compartments providing large amplitudes of Ca2+ signals to achieve synaptic plasticity, provide sites for newer synapses ...
Arehally M. Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Tousif Ahmed Hediyal, Praveen Raj, Annan Gopinath Rathipriya, M. Walid Qoronfleh, Musthafa Mohamed Essa, Saravana Babu Chidambaram   +8 more
doaj   +1 more source

Conditional RAC1 knockout in motor neurons restores H-reflex rate-dependent depression after spinal cord injury

Scientific Reports, 2021
A major complication with spinal cord injury (SCI) is the development of spasticity, a clinical symptom of hyperexcitability within the spinal H-reflex pathway.
Curtis A. Benson, Kai-Lan Olson, Siraj Patwa, Marike L. Reimer, Lakshmi Bangalore, Myriam Hill, Stephen G. Waxman, Andrew M. Tan   +7 more
doaj   +1 more source

Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors

eLife, 2022
Dendritic spines are the central postsynaptic machinery that determines synaptic function. The F-actin within dendritic spines regulates their dynamic formation and elimination.
Soo Jeong Kim, Youngsik Woo, Hyun Jin Kim, Bon Seong Goo, Truong Thi My Nhung, Seol-Ae Lee, Bo Kyoung Suh, Dong Jin Mun, Joung-Hun Kim, Sang Ki Park   +9 more
doaj   +1 more source