Results 1 to 10 of about 71,138 (196)

Attenuation of Synaptic Potentials in Dendritic Spines

Cell Reports, 2017
Summary: Dendritic spines receive the majority of excitatory inputs in many mammalian neurons, but their biophysical properties and exact role in dendritic integration are still unclear.
Masayuki Sakamoto, Darcy S Peterka, Rafael Yuste   +2 more
exaly   +3 more sources

Sleep deprivation alters hippocampal dendritic spines in a contextual fear memory engram [PDF]

Scientific Reports
Sleep is critically involved in strengthening memories. However, our understanding of the morphological changes underlying this process is still emerging.
Matthew Tennin, Hunter T. Matkins, Lindsay Rexrode, Ratna Bollavarapu, Tanya Pareek, Daniel Kroeger, Harry Pantazopoulos, Barbara Gisabella   +7 more
doaj   +2 more sources

Dendritic Spines Shape Analysis—Classification or Clusterization? Perspective

Frontiers in Synaptic Neuroscience, 2020
Dendritic spines are small protrusions from the dendrite membrane, where contact with neighboring axons is formed in order to receive synaptic input.
Ekaterina Pchitskaya, Ilya Bezprozvanny   +1 more
exaly   +3 more sources

DeepD3, an open framework for automated quantification of dendritic spines. [PDF]

PLoS Computational Biology
Dendritic spines are the seat of most excitatory synapses in the brain, and a cellular structure considered central to learning, memory, and activity-dependent plasticity.
Martin H P Fernholz, Drago A Guggiana Nilo, Tobias Bonhoeffer, Andreas M Kist   +3 more
doaj   +2 more sources

Homosynaptic plasticity induction causes heterosynaptic changes at the unstimulated neighbors in an induction pattern and location-specific manner

Frontiers in Cellular Neuroscience, 2023
Dendritic spines are highly dynamic structures whose structural and functional fluctuations depend on multiple factors. Changes in synaptic strength are not limited to synapses directly involved in specific activity patterns.
Ali Özgür Argunsah, Ali Özgür Argunsah, Inbal Israely   +2 more
doaj   +1 more source

Automated spatio-temporal analysis of dendritic spines and related protein dynamics. [PDF]

PLoS ONE, 2017
Cofilin and other Actin-regulating proteins are essential in regulating the shape of dendritic spines, which are sites of neuronal communications in the brain, and their malfunctions are implicated in neurodegeneration related to aging.
Vincent On, Atena Zahedi, Iryna M Ethell, Bir Bhanu   +3 more
doaj   +1 more source

Automated Remote Focusing, Drift Correction, and Photostimulation to Evaluate Structural Plasticity in Dendritic Spines. [PDF]

PLoS ONE, 2017
Long-term structural plasticity of dendritic spines plays a key role in synaptic plasticity, the cellular basis for learning and memory. The biochemical step is mediated by a complex network of signaling proteins in spines.
Michael S Smirnov, Paul R Evans, Tavita R Garrett, Long Yan, Ryohei Yasuda   +4 more
doaj   +1 more source

Electrotonic signals along intracellular membranes may interconnect dendritic spines and nucleus. [PDF]

PLoS Computational Biology, 2008
Synapses on dendritic spines of pyramidal neurons show a remarkable ability to induce phosphorylation of transcription factors at the nuclear level with a short latency, incompatible with a diffusion process from the dendritic spines to the nucleus.
Isaac Shemer, Björn Brinne, Jesper Tegnér, Sten Grillner   +3 more
doaj   +1 more source

Sevoflurane exposure may cause dysplasia of dendritic spines and result in fine motor dysfunction in developing mouse through the PI3K/AKT/mTOR pathway

Frontiers in Neuroscience, 2022
Sevoflurane has become one of the most widely used volatile anesthetics in pediatric surgery. However, sevoflurane exposure may interfere with dendritic development and synaptogenesis, resulting in brain function impairment.
Linhong Zhong, Xiaofan Ma, Yixuan Niu, Lei Zhang, Zhenyu Xue, Jia Yan, Hong Jiang   +6 more
doaj   +1 more source

Increased spine PIP3 is sequestered from dendritic shafts

Molecular Brain, 2022
Phosphatidylinositol 3,4,5-trisphosphate (PIP3) is a lipid second messenger that is crucial for the synaptic plasticity underlying learning and memory in pyramidal neurons in the brain. Our previous study uncovered PIP3 enrichment in the dendritic spines
Yoshibumi Ueda, Naotoshi Sugimoto, Takeaki Ozawa   +2 more
doaj   +1 more source