Results 21 to 30 of about 261,993 (301)
Study of dendritic spine compartmentalization : a correlative fluorescence light microscopy-electron microscopy approach [PDF]
, 2014 Neurons communicate with each other through synapses. Most excitatory synapses contact small protrusions called dendritic spines. Spines are connected to dendrites by a very thin stalk called the “spine neck” which restricts diffusion between the spine ...
Cyprien, Vivien
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The role of dendritic spines in epileptogenesis. [PDF]
Front Cell Neurosci, 2023 Epilepsy is a chronic central nervous system (CNS) disease associated with high morbidity. To date, there is no known disease-modifying therapy for epilepsy. A leading hypothesis for a mechanism of epileptogenesis is the generation of aberrant neuronal networks.
Jean G, Carton J, Haq K, Musto AE.
europepmc +4 more sources
"Role of the neuronal protein Cap23 in the maturation and maintenance of dendritic arbors in-vivo" [PDF]
, 2006 Dendrites in the central nervous system are the postsynaptic counterparts in the neural circuitry, and the principal sites of excitatory synaptic inputs.
Sadhu, Anirban
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eLife, 2023 Microglia, the resident immune cells of the brain, play a complex role in health and disease. They actively survey the brain parenchyma by physically interacting with other cells and structurally shaping the brain.
Felix Christopher Nebeling +6 more
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Gelsolin : a regulator of postsynaptic actin assembly and AMPA receptor expression [PDF]
, 2003 Dendritic spines are the postsynaptic contact sites for the majority of excitatory synapses in the brain. Synaptic activity influences the number, shape and motility of dendritic spines and these effects are likely mediated by dynamic actin filaments,
Zhao, Pingwei
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Automated analysis of spine dynamics on live CA1 pyramidal cells [PDF]
, 2015 Dendritic spines may be tiny in volume, but are of major importance for neuroscience. They are the main receivers for excitatory synaptic connections, and their constant changes in number and in shape reflect the dynamic connectivity of the brain.
Vetter, Thomas +13 more
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Regulation of dendritic spine morphogenesis and synapse formation by copines [PDF]
, 2006 Primary rat hippocampal culture is a well established system to study molecular mechanisms occurring during synapse formation and maturation. By closer analysis of the temporal appearance of presynaptic Bassoon and the postsynaptic proteins SynGAP, PSD ...
Galic, Milos
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Neural Plasticity, 2016 Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory. However, our knowledge about molecular mechanisms that regulate the development and maintenance of dendritic spines is limited.
Xiaohua Jin +7 more
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PLoS Computational Biology, 2022 Dendritic spines are highly dynamic neuronal compartments that control the synaptic transmission between neurons. Spines form ultrastructural units, coupling synaptic contact sites to the dendritic shaft and often harbor a spine apparatus organelle ...
James Rosado +5 more
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The discovery of dendritic spines by Cajal [PDF]
Frontiers in Neuroanatomy, 2015 Dendritic spines were considered an artifact of the Golgi method until a brash Spanish histologist, Santiago Ramón y Cajal, bet his scientific career arguing that they were indeed real, correctly deducing their key role in mediating synaptic connectivity.
openaire +3 more sources