Results 31 to 40 of about 261,993 (301)
Structure-function analysis on the level of individual synapses [PDF]
, 2010 Excitatory synapses in the mammalian brain are made on small protrusions of the postsynaptic cell called dendritic spines. Dendritic spines are highly variable in their morphology and in their microanatomy (e.g. presence of subsynaptic organelles). It is
Holbro, Niklaus
core +1 more source
3D morphology-based clustering and simulation of human pyramidal cell dendritic spines.
PLoS Computational Biology, 2018 The dendritic spines of pyramidal neurons are the targets of most excitatory synapses in the cerebral cortex. They have a wide variety of morphologies, and their morphology appears to be critical from the functional point of view. To further characterize
Sergio Luengo-Sanchez +5 more
doaj +1 more source
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice [PDF]
, 2010 The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) peptide, hyperphosphorylated tau protein, neuronal death, and synaptic loss.
Fuhrmann Martin +28 more
core +2 more sources
Pathology of Synapses and Dendritic Spines
Neural Plasticity, 2012 Peer ...
Shira Knafo +3 more
openaire +4 more sources
The function of Copine 6 in the brain [PDF]
, 2012 The formation of new or the remodeling of pre-existing synapses is thought to provide the cellular correlate of learning and memory processes. In the mammalian forebrain, the postsynaptic site of most excitatory synapses is located on dendritic spines ...
Reinhard, Judith
core +1 more source
The Kainate Receptor Subunit GluK2 Interacts With KCC2 to Promote Maturation of Dendritic Spines
Frontiers in Cellular Neuroscience, 2020 Kainate receptors (KAR) play a crucial role in the plasticity and functional maturation of glutamatergic synapses. However, how they regulate structural plasticity of dendritic spines is not known.
Sebnem Kesaf +14 more
doaj +1 more source
The spine problem: finding a function for dendritic spines
Frontiers in Neuroanatomy, 2014 Why do neurons have dendritic spines? This question-the heart of what Yuste calls "the spine problem"-presupposes that why-questions of this sort have scientific answers: that empirical findings can favor or count against claims about why neurons have spines. Here we show how such questions can receive empirical answers.
Malanowski, Sarah, Craver, Carl F.
openaire +3 more sources
Biological Research, 2023 Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic pain.
Qiaoyun Wu +10 more
doaj +1 more source
Calcium Dynamics in Dendritic Spines and Spine Motility [PDF]
Biophysical Journal, 2004 A dendritic spine is an intracellular compartment in synapses of central neurons. The role of the fast twitching of spines, brought about by a transient rise of internal calcium concentration above that of the parent dendrite, has been hitherto unclear.
Holcman, D., Schuss, Z., Korkotian, E.
openaire +2 more sources
Frontiers in Neuroanatomy, 2014 Units of dendritic branches called dendritic spines represent more than simply decorative appendages of the neuron and actively participate in integrative functions of ‘spinous’ nerve cells thereby contributing to the general phenomenon of synaptic ...
Saturnino eSpiga +3 more
doaj +1 more source